Aug 22 • 🔬Science
Leptin & fatloss
A quick breakdown of how leptin relates to fat loss.
✅ What is Leptin?
• Leptin is a hormone produced by fat cells.
• It signals to your brain (specifically the hypothalamus) that you have enough energy stored, helping regulate hunger and metabolism.
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✅ Leptin’s Role in Fat Loss
• When body fat is high, leptin levels are high → signals satiety → reduces appetite.
• When you diet and lose fat, leptin levels drop →
brain thinks you’re starving → increases hunger and slows metabolism (a survival mechanism).
• This is why long-term dieting can feel harder: lower leptin means more cravings and lower calorie burn.
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✅ Leptin Resistance
• In obesity, even though leptin levels are high, the brain stops responding effectively (similar to insulin resistance).
• Result: Constant hunger despite enough fat stores.
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✅ Can You “Boost” Leptin for Fat Loss?
You can’t take leptin supplements effectively (except in rare medical cases).But you can manage leptin signaling:
• Avoid chronic severe calorie restriction (causes big leptin drops).
• Sleep well — sleep deprivation lowers leptin and increases ghrelin (hunger hormone).
• Strength training helps maintain metabolism while dieting.
• Refeed days or diet breaks (short-term higher carbs) can temporarily raise leptin.
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🔥 Bottom line:Leptin is key for appetite control and metabolic rate, but you can’t hack it with pills — you need smart dieting strategies to keep leptin from tanking.
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Leptin & fatloss
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