Use Data Tables to look for duplicates

Does anyone have a good video or article that explains how I would avoid writing duplicate entries to a data table? I need to know the most efficient way, as I have a very large data table and I don't want to run into memory issues. Essentially, I need to check if the entry exists (using a match condition probably), and if it does not exist write to the data table. If it does already exist, I don't want it to write a duplicate entry. Thanks for the advise! 🙏

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