Introduction to GSH (Glutathione-Cysteinyl-Glycine)

The primary ingredient in Immunocal is a proprietary, undenatured whey protein isolate that is rich in bonded cysteine, an essential precursor for your body to produce its own glutathione (GSH).

Core Ingredients:

Undenatured Whey Protein Isolate: This is the main component of all Immunocal products. It is a high-purity protein that is a natural source of the amino acid cysteine (in its stable form, cystine), which is the rate-limiting factor in glutathione synthesis in the body.

Ingredients in Specific Immunocal Products:

Immunocal Platinum:

The Platinum version has the same core whey protein isolate as the original, but with two added proprietary blends:

Cytokine Modulating Peptides (CMP)™: These are small proteins intended to help regulate inflammation.
Redox Modulating Formula (RMF)™: A blend of natural citrate minerals (potassium, magnesium, and calcium) and creatine, designed to help maintain proper muscle function and support the body's natural pH balance.

Immunocal Sport:

The Sport version is formulated with additional ingredients to enhance athletic performance and recovery:

Undenatured Whey Protein Isolate: The glutathione precursor base.
L-Citrulline and Beet Root Extract: These ingredients are intended to boost nitric oxide production, which improves blood flow and endurance.
Tart Cherry Extract: An antioxidant-rich component to help reduce muscle soreness and improve recovery.
Magnesium: An essential mineral that aids in muscle recovery.

Immunocal Booster:

This is a separate superfood supplement, intended to be used alongside the protein powder. Its ingredients include:

Nrf2 Catalyst™ blend with Sulforaphane (from broccoli seed extract) and Selenium: These activate the body's internal antioxidant defense system (the Nrf2 pathway).
Over 50 organic fruits and vegetables phytonutrient blend.
Vitamins A, K, C, E, and B12.
Some versions also include natural sources of caffeine from green tea, green coffee, and guarana extracts.

ABOUT GSH:

GSH is the standard biochemical abbreviation for the reduced form of glutathione: (𝛾gamma-L-glutamyl-L-cysteinyl-glycine), which is the body's primary antioxidant and detoxifying agent found in high concentrations in all mammalian tissues.

It acts as the active, protective form of the molecule, neutralizing reactive oxygen species (ROS) and donating electrons to reduce oxidative stress, becoming oxidized glutathione (GSSG) in the process.

In biology, glutathione exists in two main states:

Master Antioxidant: It is the most abundant antioxidant in your cells and is critical for protecting them from oxidative damage and environmental toxins.
Detoxification: GSH binds to toxic substances in the liver to help the body excrete them.
Immune Support: It is essential for the proper functioning of white blood cells (T-lymphocytes) and helps regulate inflammation.
Redox Indicator: The ratio of GSH to GSSG is used by scientists as a primary measure of a cell's oxidative stress levels; a high GSH-to-GSSG ratio typically indicates a healthy, low-stress environment.

GSH (Reduced Glutathione) levels involves either providing your body with the "raw materials" it needs to make more or using specialized medical delivery methods to bypass the digestive system.

Boosting your GSH (Reduced Glutathione) levels involves either providing your body with the "raw materials" it needs to make more or using specialized medical delivery methods to bypass the digestive system.

Natural Ways to Boost GSH:

Because oral glutathione is often broken down in the gut before it reaches your cells, the most effective natural strategies focus on precursors like Immunocal —the building blocks of GSH.

Sulfur-Rich Foods: Sulfur is essential for GSH synthesis.Cruciferous Vegetables: Broccoli, cauliflower, kale, and Brussels sprouts.Allium Vegetables: Garlic, onions, and shallots.
Whey Protein: High-quality, non-denatured whey is one of the best sources of cysteine, the most important (and usually scarcest) amino acid needed for GSH production.
Selenium-Rich Foods: Selenium is a "cofactor" that activates enzymes like glutathione peroxidase.Sources: Brazil nuts (just 1–2 per day provides your full RDA), fish, eggs, and chicken.
Vitamin C and E: These help recycle oxidized glutathione back into its active GSH form.
Lifestyle Habits: Exercise: Regular moderate activity stimulates GSH production.Sleep: Chronic lack of sleep is linked to lower GSH levels; aim for 7–9 hours.Limit Alcohol: Excessive alcohol significantly depletes GSH, especially in the lungs and liver.

Medical and Therapeutic Uses:

In medical settings, glutathione is used to treat specific conditions where oxidative stress is extremely high.

Detoxification (NAC): N-acetyl cysteine (NAC) is a common medical supplement and hospital treatment used to replenish GSH stores, particularly for acetaminophen (Tylenol) overdoses to prevent liver failure.
IV Therapy: Intravenous GSH is used to bypass the digestive tract. It is sometimes used to:Reduce nerve damage and toxicity from chemotherapy (e.g., cisplatin).Support liver health in patients with Non-Alcoholic Fatty Liver Disease (NAFLD).Provide acute antioxidant support in conditions like sepsis or severe burns.
Skin Treatments: GSH is used (orally, topically, or via IV) for skin lightening by inhibiting melanin production, though IV use for this purpose is controversial due to potential side effects like anaphylaxis.
Liposomal Supplements: For those who prefer oral options, liposomal glutathione is designed to protect the molecule from stomach acid, offering better absorption than standard pills.

Potential Benefits in Clinical Research & Use:

Scientific and medical publications have explored the potential of Immunocal in managing conditions associated with low glutathione or high oxidative stress, including:

Autism: Studies have shown that some children with autism have abnormally low glutathione levels and increased oxidative stress markers. Clinical studies have investigated whether Immunocal can improve these metabolic imbalances and show a trend toward an improvement in autistic behaviors, though further research is needed.
Parkinson's Disease: The depletion of GSH is a documented factor in neurodegenerative disorders like Parkinson's disease. Research in animal models suggests that raising GSH levels in the brain with a cysteine-rich supplement like Immunocal may offer neuroprotective benefits, but human clinical studies have reported increased plasma glutathione without significant changes in clinical outcomes.
Inflammation: Immunocal's action is primarily through boosting the body's master antioxidant, which helps protect cells from damage and regulate immune function. One of the additional ingredients in the Immunocal Booster product is specifically noted for helping to relieve inflammation.
Other Conditions: Immunocal has been tested in human clinical trials for a range of other conditions including:
Cystic Fibrosis
HIV/AIDS
Cancer-related weight loss
Obstructive Lung Disease
Enhanced athletic performance and recovery

If any of this resonates with you, the next step is simple.

For full educational access — including symptom-specific playlists — you’ll need to register through my link. Just click below and watch the short overview video from our President, Mike Potillo. He clearly explains what Immunocal is, how it supports glutathione production, and why that matters.

https://www.immunotec.com/en-US/mullins/page/bodyshot

From there, you can explore the training library and look up the areas that interest you most.

Education first.

Decisions second.

And I’m here if you have questions.

Grandma Grady,

Your Immunotec Consultant

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