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Owned by Travis

BioOptimization Collective

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Unlock energy, build lean muscle, burn fat, and balance hormones. Join the tribe redefining health and performance for men & women 35+.

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91 contributions to BioOptimization Collective
Can You Microdose Retatrutide?
Let’s Clear This Up. This comes up a lot, so I want to reframe an important point. When someone tells me they’re “microdosing” retatrutide because they’re splitting a 2 mg weekly dose into four 500 mcg injections, that is not microdosing. That’s called split dosing, and there’s a big difference. What Microdosing Actually Means In pharmacology, microdosing has a specific definition: Less than 1/100th of the dose that produces a measurable pharmacological effect. At that level: - You don’t meaningfully activate receptors - You don’t reach therapeutic blood levels - You don’t get real metabolic or appetite effects So when we’re talking about drugs like retatrutide, true microdosing does not work. What Most People Are Really Doing: Split Dosing If your total weekly dose stays the same, but you divide it into smaller, more frequent injections, that’s split dosing. Example: - 2 mg once per week - 1 mg twice per week - 500 mcg four times per week All of these add up to 2 mg per week. The total weekly dose hasn’t changed — only how it’s delivered. Why Split Dosing Can Make Sense Retatrutide has a long elimination half-life of about 6 days. That means: - After 6 days, roughly half of the injected amount is still in your system - Each new dose stacks on top of what hasn’t been eliminated yet Over time, this creates a rolling average concentration in the bloodstream. Eventually, you reach what’s called a steady state, where the amount you’re injecting equals the amount your body is eliminating. This usually takes about 4–5 half-lives, regardless of how often you inject. What matters most is total weekly dose, not injection frequency. Why Microdosing Retatrutide Doesn’t Work True microdosing never allows you to: - Reach steady state - Achieve sufficient receptor activation - Maintain concentrations high enough to produce results GLP-based drugs have a threshold effect. If you don’t reach that threshold, nothing meaningful happens.
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Trusted Research Supplies — Available on Amazon
We get asked all the time what supplies I actually use when working with research peptides. So instead of guessing, we put together a simple list of research supplies we trust and personally purchase through Amazon. These are basic, no-nonsense tools that support accuracy, cleanliness, and consistency in a research setting. Nothing fancy. Nothing gimmicky. Just reliable equipment that gets the job done. Why Amazon - Easy to source and reorder - Consistent quality and availability - Clear specs and real reviews - Fast delivery when you need it What You’ll Find This list includes commonly used lab and research supplies, such as: - Precision measurement tools - Sterile handling and storage items - Labeling and organization supplies - General accessories that support clean research practices I use these because they’re practical, dependable, and proven—not because they’re trending on social media. Important Reminder Everything shared here is for research and educational purposes only. Nothing is intended for human consumption, medical use, or treatment. The goal is simple: remove confusion, save time, and help you follow best practices so you can focus on learning and doing things the right way. Start simple. Stay organized. Be precise. That’s how real research is done. Link for Reconstitution Solution: https://a.co/d/041SVcEm Link for Alcohol Prep Pads: https://a.co/d/0fX2kyaL Link for 1mL, 29 Gauge, 1/2 inch Syringes: https://a.co/d/0c8tbJvb
Trusted Research Supplies — Available on Amazon
How to Use the Bio-Optimized Calculator for Research Peptides
This calculator is a research planning tool. https://peptide-prep-buddy.lovable.app/ It helps you: - Measure correctly - Stay consistent - Plan how long your research materials will last - Avoid mistakes and waste It does not give medical advice or tell you how to use anything on people. It only helps with math and planning. How to Think About Research Peptides Imagine you are doing a science project with: - A container of powder - Water to mix it - A measuring tool If you do not measure the same way each time. - Results are inconsistent - Material gets wasted - Planning becomes difficult This calculator helps you measure the same way every time. Step-by-Step: What to Enter 1. Vial Amount (mg) This is how much research material is in the vial. Examples: - 5 mg - 10 mg Enter the number exactly as it appears on the vial label. This tells the calculator how much total material you are working with. 2. Water Added (mL) This is how much liquid you added to mix the vial. Examples: - 1 mL - 2 mL Adding more water does not add more peptide. It only spreads the same amount over more liquid. 3. Target Amount (mcg) This is the size of one measured portion. Examples: - 100 mcg - 250 mcg Smaller amounts mean more portions per vial. Larger amounts mean fewer portions per vial. This step controls how long the vial will last. 4. Syringe Type This tells the calculator how your measuring tool is marked. Options: - U-100 (most common) - U-40 (less common) - mL only (liquid markings, no units) Always choose the option that matches the syringe you are using. If this is wrong, the math will be wrong. 5. Syringe Size (Capacity) This is how much liquid the syringe can hold. Common sizes: - 0.3 mL - 0.5 mL - 1.0 mL This helps prevent trying to draw more liquid than the syringe can hold. What the Calculator Shows You Concentration This tells you how strong the liquid is after mixing.
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How to Use the Bio-Optimized Calculator for Research Peptides
The Reality Check Most People Miss
Six hours of sleep isn’t ideal—but pretending it’s eight doesn’t make it so. If your schedule is fixed, the smartest move isn’t chasing supplements or sedatives. It’s engineering depth, timing, and recovery efficiency inside the window you actually have. That means: - Falling asleep faster - Spending a higher percentage of the night in slow-wave sleep - Making sure GH and melatonin are peaking inside your sleep window—not outside it Peptides don’t replace sleep. They increase the return on each hour when the duration is capped. This Is About Compression, Not Hacking: The mistake people make is trying to force sleep: - More pills - More sedation - More unconsciousness That usually backfires by flattening deep sleep and fragmenting REM. The approach outlined here does the opposite: - Calm the nervous system without sedation - Bias sleep toward delta waves - Amplify the recovery signals that already occur during deep sleep - Align circadian timing so those signals happen when you’re actually asleep You’re not extending the night. You're compressing more restoration into it. One More Time, Plainly: If you’re stuck at ~6 hours, the hierarchy is: 1. Onset speed – Don’t waste 45 minutes lying awake 2. Slow-wave density – More deep sleep per hour 3. GH efficiency – Bigger recovery signal during SWS 4. Circadian timing – Right sleep at the right biological time Everything in the stack maps to one of those levers. Don’t Skip the Boring Stuff: No peptide overrides these: - Same bed and wake time, even on weekends - Dark room, cool temperature, zero light leaks - Caffeine out by early afternoon - Alcohol nowhere near bedtime - Last real meal 3–4 hours before sleep If those are broken, peptides just make an expensive mess. Bottom Line: If eight hours isn’t happening, stop pretending it will. Build a protocol that: - Gets you asleep faster - Pushes you deeper - Makes your GH pulses count - Keeps your circadian rhythm honest
The Reality Check Most People Miss
1 like • 3d
@Kimberly Kelly have you had recent full blood panel done? If so send it over and and we can analyze to see what your body needs.
1 like • 3d
@Kimberly Kelly The Stack (Conceptual) - DSIP: Reduces sleep latency and biases EEG activity toward delta waves without sedation. - Epithalon: Supports pineal signaling, improves melatonin rhythm amplitude, and enhances sleep depth and consolidation. - CJC-1295 (No DAC) + IpamorelinAmplifies natural growth hormone pulses during slow-wave sleep, increasing recovery efficiency rather than frequency. - Low-dose melatonin (optional) Used only as a circadian anchor to ensure hormonal signals peak during the actual sleep window, not outside it. This is signal alignment and amplification, not pharmacological sedation.
1 like • 5d
@Wendy Aguilar, we have a couple of options through our partnerships. These are the 2 options to have done through us or your provider. Option 1: Female Comprehensive Hormone Panel (Pre-Built Panel) Name: Female Comprehensive Hormone Panel (LC/MS/MS) Price: $403 Key Features: - HSA/FSA accepted - Instant lab order - No doctor’s visit required - No insurance required - Uses LC/MS/MS testing (gold standard for hormone accuracy) What This Panel Is Designed To Do: - Pinpoint causes of hormonal imbalances - Reveal underlying issues affecting mood - Clarify reasons for unexpected weight changes Important Testosterone Note: - Testosterone results reported from 0–9,999 - If levels exceed 9,999, results will display “>10,000” - Uses advanced lab methods for precise testosterone measurement What’s Included in This Panel: - Complete Blood Count (CBC) with Differential & Platelets - Comprehensive Metabolic Panel (CMP) with eGFR - Lipid Panel - Testosterone (Free & Total) – LC/MS/MS - Estrogen, Total - Estradiol - Progesterone - Pregnenolone – LC/MS - DHEA-S (DHEA Sulfate) - TSH - Free T3 Best For: - Women who want a done-for-you, comprehensive snapshot - Those dealing with fatigue, mood changes, weight issues, or hormone symptoms - Anyone who wants high-accuracy hormone data without customizing labs Option 2: Build a Custom Panel (À La Carte Approach) Name: Build Custom Panel How It Works: - You select individual labs instead of buying the full bundled panel - Pricing varies depending on which labs are chosen - Allows personalization based on symptoms, goals, or budget Potential Advantages: - Can reduce cost if fewer markers are needed - Targeted testing for specific concerns (thyroid only, sex hormones only, etc.) - Useful for follow-up testing or trend tracking Common Labs You Might Select Individually: - Testosterone (Free & Total – LC/MS/MS) - Estradiol - Progesterone - DHEA-S - Pregnenolone - TSH / Free T3 - Lipids - CMP or CBC (optional)
0 likes • 5d
Option 2 cost is $272.
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Travis Dickey
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158points to level up
@travis-dickey-2146
I’m here for people 35+ who refuse to decline. We’ll optimize body, mind & business to reclaim power & build a legacy.

Active 16h ago
Joined Aug 24, 2025
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