Looking for some guidance- my 20 year old son has been battling eczema for the last couple of years. After a strict diet change (gf no dairy) some gut rebuilding and 1 cycle of GHK KPv - big improvement (almost fully cleared up). Took a 2 week break then restarted and it is now 10x worse. He trains 4x a week but his job (server) can be long hours and the sweat makes things worse.

Creating this space has genuinely been a dream come true. Being able to have thoughtful conversations, challenge ideas, learn out loud, and walk alongside people as they navigate their health has been incredibly meaningful to me. I don’t take it lightly that you choose to spend your time here, ask questions, give feedback, and share your experiences. That trust matters. What excites me most isn’t just protocols or tools it’s the mindset I see here. People being proactive instead of reactive. People choosing to learn, to stay curious, and to take ownership of their health. That kind of curiosity is powerful, and honestly, it makes this work fun. Health should feel empowering, not overwhelming, and learning should feel like an invitation, not a burden. I’m deeply grateful for the support, the conversations, the respectful disagreements, and the encouragement. This community pushes me to think more clearly, teach better, and keep refining my own understanding. I’m committed to continuing to learn, to get better, and to show up fully as part of this process alongside you, not above it. Looking ahead, I’m really excited about what’s coming next year. I’ll be expanding ways to work together more closely beyond one-off consults, for those who want deeper guidance and continuity. That said, this space will always be rooted in generosity, shared learning, and mutual respect. If you’re enjoying the conversations here, know that I care just as much about this community as I do about any one-on-one work. Thank you for being here, for being curious, and for being part of something that feels genuinely special. I’m grateful for every one of you, and I’m looking forward to continuing this journey together.

True healing happens when inflammation completes its full life cycle initiation, resolution, and regeneration. Part 1 explained the molecular language that allows this to happen: plasmalogens providing structural resilience and SPMs sending the biochemical “stand down” signal. Part 2 translates that science into practice how to rebuild this communication system through nutrition, supplementation, and targeted protocols that restore the body’s ability to self-regulate. Re-establishing the Resolution Loop In chronic disease, the inflammatory cycle stalls between the attack and repair phases. The body keeps releasing cytokines like TNF-alpha and IL-6, but never transitions to the clean-up molecules such as resolvins or maresins. The therapeutic goal is not to shut off inflammation but to reopen the loop so that the same immune cells that fought can now rebuild. That means supplying the missing raw materials, reactivating the enzymes that make SPMs, and rebuilding the membranes that store them. Step 1: Rebuild the Substrate Plasmalogen Restoration The first step is to fix the infrastructure. Without plasmalogens, cell membranes lose flexibility, mitochondrial function suffers, and omega-3 reserves for SPM production vanish. The quickest way to rebuild this pool is through precursors like Prodrome Neuro and Prodrome Glia, which contain ether-linked lipid backbones that bypass the damaged peroxisomal step. Taken daily, they replenish both phosphatidylcholine- and phosphatidylethanolamine-based plasmalogens. In practice, most people use six capsules of each per day for a repletion phase lasting three to six months, followed by a maintenance dose of two to four daily. The improvement is gradual but measurable patients often report clearer cognition, calmer mood, and reduced oxidative stress within eight weeks as their membranes regain elasticity. Step 2: Supply the Builders Cofactors for Peroxisomes Even when precursors are provided, the enzymes that finish plasmalogen synthesis need help. B-vitamins act as catalysts; magnesium stabilizes ATP; zinc and iron activate the transferases that move fatty chains; and CoQ10 supports the redox cycling inside the peroxisome. A simple daily stack vitamin B3 (as niacinamide 250 mg), vitamin B5 (as pantothenate 500 mg), magnesium glycinate (200–400 mg), zinc (15–30 mg), and CoQ10 (100 mg) creates the metabolic environment for these pathways to work. This foundational nutrition turns the “factory lights” back on so that plasmalogens can be built efficiently rather than burned.

Every athlete, coach, and biohacker eventually runs into the same frustration: why does progress sometimes explode forward and other times stall no matter how hard you train or how clean you eat? The answer is not just “train harder” or “add more supplements.” The truth is that your body runs on a set of master switches that decide whether energy goes into building, burning, or repairing. These switches are called mTOR, AMPK, and sirtuins. They are the hidden dials that determine muscle growth, fat loss, recovery, and even how long and well you live. Think of your body like a hybrid supercar. mTOR is the turbocharger, pumping out raw power when you slam on the gas. AMPK is the hybrid battery system, kicking in when fuel is low and efficiency is everything. Sirtuins are the mechanics and quality inspectors, making sure the system does not overheat and burn itself out. When you know how to control these systems, you stop guessing. You can decide when to push growth, when to trigger fat burning, and when to repair and restore. This article will walk you through how these pathways work, how they interact, and how you can actually use this science in your training, nutrition, and recovery. Whether you are a strength coach, a cellular medicine professional, or a biohacker experimenting with protocols, this will give you an immediately actionable framework. The Three Pillars of Metabolic Control mTOR – The Builder mTOR stands for mechanistic target of rapamycin, and it is the master controller of growth. If you imagine a construction site, mTOR is the foreman shouting orders to workers. When protein, carbs, and growth signals like insulin and IGF-1 are present, the foreman calls in the crews to build new skyscrapers—your muscles. This is why post-workout meals rich in protein and carbs stimulate recovery and hypertrophy. But there is a problem. If the foreman never rests and keeps trying to build nonstop, the job site gets messy. Too much mTOR signaling without breaks leads to insulin resistance, cellular junk buildup, and accelerated aging. In real life, this looks like someone who bulks hard with constant high-calorie intake and plenty of lifting but ends up inflamed, sluggish, and metabolically unhealthy. So mTOR is powerful, but it has to be pulsed, not left on all the time.

My fiancé has been dealing with some peculiar issues that I’m trying to connect the dots on and would love input. She had lower leg swelling in the past that eventually resolved, and a remote history of Morton’s neuroma that hasn’t been symptomatic for years. Right now her main struggles are poor sleep, consistently low energy, chronic back tightness, and most notably significant thumb pain with joint locking. She describes it as if the thumb “needs to be pulled out.” Both sides were affected at first, but interestingly the untreated side resolved spontaneously while the PRP-treated side continues to be painful and lock regularly. Her job as a personal trainer and working retail means a lot of daily standing, hand and wrist loading, and repetitive strain. Emotionally, she’s carried stress since her father passed away three years ago she handled it well but still has difficult days. Nutritionally, she was vegetarian for about 40 years before introducing chicken 5–6 years ago, but otherwise eats minimal animal protein. My working thought is that this may not just be an isolated tendon or joint problem but a systemic terrain issue possibly a fibrosis-prone environment that explained the paradoxical PRP result, along with lymphatic or vascular fragility from standing all day, circadian and mitochondrial dysfunction contributing to poor energy and recovery, long-term nutrient debt from decades of vegetarianism (creatine, carnitine, B12, zinc, glycine, proline, lysine), and stress physiology from her HPA axis that stiffens fascia and keeps her in sympathetic tone. I’ve sketched out a phased protocol: first reset terrain with circadian support (melatonin or Epitalon), mitochondrial stack (SS-31, Kenetik Pro, plasmalogens), lymphatic strategies (compression, walking, electrolytes), and add Amlexanox as a fibrosis/inflammation reset. Then in phase 2, move to matrix remodeling with BPC-157, TB4, Pentosan Polysulfate, phosphatidylcholine, local tendon glides, red light, topical magnesium, and NeuFit or PEMF for fascia and back tightness, alongside nutrient repletion with collagen peptides, vitamin C, glycine/proline, zinc, copper, and manganese. Finally in phase 3, focus on integration and resilience with Epitalon cycles, MOTS-c, sauna and cold contrast, tendon-friendly strength training, strict sleep hygiene, and nutrient support like creatine, carnitine, and DHA/EPA. I’d re-evaluate with imaging if the thumb pain and locking persist or run labs if swelling recurs. My questions are: does Amlexanox make sense as a first step to rebalance the inflammatory/fibrotic terrain before PPS or repeat PRP? Is the PRP paradox more likely a redox/cellular terrain issue or immune imbalance? And am I over-attributing her back tightness and energy issues to systemic inflammation/lymphatics, or does that reasoning fit? Would love to hear how you all would think through this. @Elizabeth Yurth @Cynthia Keller @Carl Paige @Eric Fete @Eric Serrano anyone else! I’m here to learn and I want to be able to help her.