Hey everyone, I’m a longtime friend of Lane and have followed his journey since the beginning back when he started his first YouTube channel. You won’t find a better guy! When he started sharing his fitness journey, I knew he was someone I could trust, and honestly his story really kicked my own health journey into overdrive. I started taking Tirzepatide on April 12, and as of today, May 27, I’m down 30 pounds!!! It definitely hasn’t been easy every day. At first, I was skeptical because the shots made me feel like I had a stomach bug for about a day after taking them. But after the first couple weeks, that feeling pretty much went away, and now it just works by quieting the constant hunger signals. I’ve also been trying to do this the right way by hitting the gym at least 3 times a week and walking or running 5 times a week because I didn’t want to lose my guns either 😂 I say all that because if you joined this group and you’re skeptical about GLP-1s, you’re in the right place. I know Lane puts in hours and hours of research to make sure he’s giving people good information, and I’m really grateful he’s been willing to be vulnerable and share his journey publicly. I still have a ways to go, but I already feel so much better and definitely feel like I’m finally headed in the right direction.

Hi everyone I am a 68 year old doctor from Pune, India. Being a general medicine doctor and a specialist in sexology, I have great interest in hormones, neuro-chemicals and their metabolic processing in the human body. Just wanted to share a detailed information regarding my experience with Tirzepatide. It has now been about 10 weeks since I started treatment, and I’ve lost around 5 kilos (11 pounds) so far. Also started TRT alongside. I am just about 12 kilos above my ideal weight but most of it is centred around my abdomen. I also was undergoing treatment for diabetes and hypertension. After starting Tirzepatide-TRT combo... qualitative changes in my metabolism have been quite remarkable—my energy levels feel comparable to what I experienced in my 30s and 40s, with much better day-long consistency and reduced fatigue. One of the most noticeable shifts has been in my dietary pattern. I’ve purposely gravitated toward a high-protein, high-fiber diet with significantly reduced carbohydrate intake. It didn't require much conscious effort for appetite modulation my satiety signaling got intrinsically altered. My cravings, particularly for refined carbs, have reduced substantially. Alongside this, I’ve been consistent with gym workouts, and I can clearly see improvements in muscle strength and endurance. My tennis performance, in particular, has improved to a level where I genuinely feel I’m playing with the agility and stamina of my younger years. Recovery times are also better. From a physiological standpoint, this has been a fascinating experience. My current understanding is that relative deficiency or impaired signaling of incretins like GLP-1 and GIP contributes significantly in improving health of persons with insulin resistance responsible for dysregulated appetite resulting in weight gain, with eventual progression to type 2 diabetes. The correction of this axis at the basic level appears to have profound systemic effects. What is particularly intriguing—especially from a medical perspective—is the broader neurohormonal interplay. The downstream effects of GLP-1 and GIP modulation on central appetite pathways, and possibly on other neurotransmitter systems, including endorphins and endocannabinoids, open up an entirely new dimension of metabolic regulation. The improvement in motivation, mood, and reward-driven eating behavior suggests that these agents are not merely metabolic drugs but neuro-metabolic modulators.