Most of your favorite peptides probably have something to do with weight loss or body composition. That's part of why ARA-290 gets overlooked. It's ultimate purpose is for repair and anti-inflammation. It's a synthetic peptide derived from erythropoietin (EPO) but without the cardiovascular risks. They essentially isolated the repair components that help with neuroprotection and tissue-protection while getting rid of the part that stimulated red blood cell production. ARA-290 binds to something called the innate repair receptor (IRR). These receptors are formed and appear on the outside of localized areas where severe metabolic stress, low oxygen, or tissue injury exists. This is basically a receptor that can be targeted to create a shift in the local environment that may be pro-inflammatory and tissue-damaging and turn it around into a healing and tissue repair environment by reducing cytokine production and enhancing some tissue repair processes. If you read the Immune System course, cytokines are your immune system's inflammatory signaling molecules that are driving inflammation for various reasons throughout the body. In animals, they actually observed long-term relief after sciatic nerve injury, and that relief came FAST. In humans, they've looked at it for small fiber neuropathy. Small fiber neuropathy is the nerve damage that can cause burning, tingling, and pain. In the sarcoidosis group, it significantly helped with neuropathic and autonomic symptoms and 28-days of treatment was actually able to initiate regrowth of small nerve fibers in the cornea. The same thing happened in the type 2 diabetes patients, but they also had a better metabolic profile (so pay attention to that side of things if using). In all populations, there were really no significant adverse effects. From personal experience, I can tell you that within 4 days, my sciatic pain was almost completely gone. Before ARA-290, I was limping around half of the day. The reconstitution protocol is in the classroom over in the paid community as well because this one can be a bit tricky.