Struggling With Energy Levels on A GLP-1
If you're someone who's already battling fatigue throughout the day, and GLP-1s are making it even worse, you're not alone. Let's talk about what's actually happening and some cutting-edge solutions being researched. Why GLPs Can Make Fatigue Worse GLP-1 medications slow gastric emptying and reduce caloric intake significantly. When you're already running on fumes, this can create a perfect storm: reduced nutrient absorption, lower energy availability, and metabolic adaptation that leaves you dragging even more. Research-Backed Options to Consider MOTS-c (Mitochondrial-Derived Peptide) This 16-amino acid peptide is naturally produced in your mitochondria and acts as a metabolic regulator. Research shows it: - Enhances mitochondrial function and energy production - Improves insulin sensitivity - Supports metabolic flexibility during caloric restriction - May help counteract age-related mitochondrial decline The key: MOTS-c could help your cells produce energy more efficiently, even when calories are restricted. 5-Amino-1MQ This small molecule works by inhibiting NNMT (nicotinamide N-methyltransferase), which: - Increases NAD+ availability at the cellular level - Supports fat metabolism and energy production - May improve metabolic rate during weight loss - Helps preserve lean muscle mass Why it matters: When you're on GLPs and eating less, maintaining metabolic efficiency is crucial. NAD+ Supplementation/IV Therapy NAD+ (nicotinamide adenine dinucleotide) is essential for cellular energy production: - Required for mitochondrial ATP synthesis - Declines naturally with age and caloric restriction - Critical for metabolic processes and DNA repair - Can be supplemented via sublingual, IV, or precursors (NMN, NR) The catch: Direct NAD+ supplementation may have better bioavailability than precursors for acute fatigue. SS-31 (Elamipretide) This mitochondria-targeting peptide is one of the most promising for fatigue: - Specifically targets and repairs damaged mitochondria - Improves mitochondrial efficiency and reduces oxidative stress - Enhances cellular energy production - Shows promise in clinical trials for fatigue-related conditions