Struggling With Energy Levels on A GLP-1

⭐

🔥

If you're someone who's already battling fatigue throughout the day, and GLP-1s are making it even worse, you're not alone. Let's talk about what's actually happening and some cutting-edge solutions being researched.

Why GLPs Can Make Fatigue Worse

GLP-1 medications slow gastric emptying and reduce caloric intake significantly. When you're already running on fumes, this can create a perfect storm: reduced nutrient absorption, lower energy availability, and metabolic adaptation that leaves you dragging even more.

Research-Backed Options to Consider

MOTS-c (Mitochondrial-Derived Peptide)

This 16-amino acid peptide is naturally produced in your mitochondria and acts as a metabolic regulator. Research shows it:

Enhances mitochondrial function and energy production
Improves insulin sensitivity
Supports metabolic flexibility during caloric restriction
May help counteract age-related mitochondrial decline

The key: MOTS-c could help your cells produce energy more efficiently, even when calories are restricted.

5-Amino-1MQ

This small molecule works by inhibiting NNMT (nicotinamide N-methyltransferase), which:

Increases NAD+ availability at the cellular level
Supports fat metabolism and energy production
May improve metabolic rate during weight loss
Helps preserve lean muscle mass

Why it matters: When you're on GLPs and eating less, maintaining metabolic efficiency is crucial.

NAD+ Supplementation/IV Therapy

NAD+ (nicotinamide adenine dinucleotide) is essential for cellular energy production:

Required for mitochondrial ATP synthesis
Declines naturally with age and caloric restriction
Critical for metabolic processes and DNA repair
Can be supplemented via sublingual, IV, or precursors (NMN, NR)

The catch: Direct NAD+ supplementation may have better bioavailability than precursors for acute fatigue.

SS-31 (Elamipretide)

This mitochondria-targeting peptide is one of the most promising for fatigue:

Specifically targets and repairs damaged mitochondria
Improves mitochondrial efficiency and reduces oxidative stress
Enhances cellular energy production
Shows promise in clinical trials for fatigue-related conditions

What makes it unique: SS-31 actually goes INTO your mitochondria and optimizes function from the inside.

Common Mistakes to Avoid:

Not eating enough

Fat loss is a marathon not a sprint
Just because you don't have an appetite doesn't mean your body just stops requiring energy
Try to find balance here (Protein & Fats first)

Sleep

Make sure you are getting enough sleep
Caloric Deficits are hard on the body and your body needs all the recovery you can get
Pro Tip: Don't eat too close to bed, slowed gastric emptying make cause sleep disruption

Caffeine Intake

Don't try to overwhelm your system with stimulants
It's gonna depend researcher to researcher but, caffeine may not be your best option and make you feel more tired
The beauty with GLPs is the appetite suppression you used to get from caffeine isn't required anymore!

Hope this helps, feel free to share tips below 👇

1:36

19 comments