Its in the past, but in my current pathfinder 1st ed. campaign, we had 2 PCs come down with Ghoul fever and couldn't break it. If my character could swap classes for one session, I'd have turned into a cleric to cure their illness or at least keep their stats from dropping. It would have definitely gone wrong when we were fighting like 6 lackeys, the brood queen, and a whale (unfortunately I can't remember what they were, but it was like octopus type humanoids). I wouldn't have hit as hard since I get a lot of bonus damage for being a swashbuckler.