Alright, so Lilly dropped their TRIUMPH-4 Phase 3 data yesterday for retatrutide. 28.7% weight loss. 71 pounds average. At 68 weeks. If you've been paying attention to triple agonists, this shouldn't be surprising. The Phase 2 data already showed us where this was headed. But now we have the Phase 3 confirmation. Here's what happened: 445 people with obesity and knee osteoarthritis. Split into three groups - 9mg retatrutide, 12mg retatrutide, and placebo. The 12mg group lost an average of 71.2 pounds. That's 28.7% of their starting weight. Compare that to tirzepatide's ~21% in Phase 3. That's 8 percentage points higher. The glucagon agonism makes the difference - you're not just suppressing appetite, you're ramping up energy expenditure and fat oxidation. Why triple agonists hit different: Retatrutide is GIP + GLP-1 + Glucagon. You already know GLP-1 from semaglutide. You know the dual combo from tirzepatide. The glucagon piece is what pushes this into a different category. - GLP-1 = appetite control - GIP = metabolic optimization - Glucagon = fat-burning accelerator You're hitting all three mechanisms simultaneously. The inflammation piece is wild: This trial was designed for knee osteoarthritis, not just weight loss. The pain results were massive: - 76% reduction in pain scores - 74% improvement in physical function - 12% of people completely pain-free by week 68 But here's what's interesting - this wasn't just about losing weight and reducing load on the joints. Retatrutide crushed inflammatory markers across the board. hsCRP dropped significantly. Triglycerides down. Blood pressure down 14 mmHg. Each component has anti-inflammatory effects. GLP-1 reduces pro-inflammatory cytokines. GIP has protective effects on bone and cartilage. Glucagon ramps up fat burning, and less adipose tissue means less inflammatory signaling. You're not just taking pressure off the knee - you're turning down systemic inflammation that's driving the pain in the first place.

Everyone's been asking me about Jay Campbell's recent podcast where he claimed GLP-1s are about to be completely shut down in the research and compounding space. His prediction? Eli Lilly is coming with lawsuits, Trump cut a deal, and by 2026 you won't be able to get sema or tirz anywhere except through prescription at their new "discounted" prices ($199-$299/month). Here's my issue: Jay spent half that podcast selling a $1,200/month follastin product. So when someone's pushing expensive products while saying affordable options of proven peptides are disappearing... 🤔 That said... Eli Lilly just hit a $1 TRILLION market cap. A monopoly on GLP-1s makes perfect business sense. And we saw what happened with SS-31—these shutdowns CAN happen fast. Speaking of SS-31, Ben and I covered that rapid shutdown in our podcast. If you want to see how quickly things can change in this space, check it out: 🎥 YouTube: https://youtu.be/oCjljZn2ZoU 🎧 Spotify: https://open.spotify.com/episode/5KkQvR4xvgYKD1hLG7vKV7 📝 Show Notes: https://open.substack.com/pub/beyondthevial/p/beyond-the-vial-episode-2-black-friday My take? I don't think it'll be as dramatic as Jay claims, but I also wouldn't completely ignore the warning. Should you stock up? Maybe. Should you panic? No. I break down the whole situation, the political angle, what this could mean for research vendors, and what you should actually do about it. Read the full article here: https://open.substack.com/pub/derekpruski/p/will-glp-1s-disappear-from-the-research?r=4jq1x8&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true ⚠️ Full disclosure: This is 100% my opinion and speculation. I don't have insider info. Just giving you my honest take based on what I'm seeing.

I want to hear YOUR peptide story. I'm looking for someone from this community who's willing to come on camera for a podcast episode. Here's what we'll cover: ✅ Your research journey - how you discovered peptides ✅ Real results - how peptides have impacted your health and life ✅ Stack breakdown - we'll go through your current protocol together ✅ Live Q&A - ask me anything you want on the spot What you need to know: - This will be recorded and published - You'll be on camera - No experience needed - just be yourself and share your story This is all about education, transparency, and showing real people getting real results. Your experience could help someone else take the first step in their own research journey. If you're open to sharing your story, shoot me a DM and let's make it happen.

Hope everyone stocked up on peptides for the next 3 years 😂 (kidding... or am I?) But for real - I haven't done a Q&A in a minute and I'm overdue. So drop ALL your questions below and I'll record a massive Q&A tomorrow answering everything you throw at me. Whatever's on your mind - let's do it. Hope you all stuffed yourselves with some great food on Thanksgiving... and maybe added a few peptides to your inventory while you were at it 😉 Quick reminder: A lot of these Black Friday/holiday sales are running through Monday, so check out peptideprice.store if you haven't already. Don't sleep on these deals. Drop your questions below 👇

Alright, I know I'm late on this one. It's been over a month since Valor launched on https://peptideprice.store and a ton of you have been asking for the facility walkthrough. That's 100% on me - I should have edited this and gotten it out way sooner. This is the main facility where we lyophilized tirzepatide in the clean room. You'll see portions blurred throughout the video - those contain addresses and location details that we have to be extremely careful about for security reasons. I appreciate your understanding on that. For me, just getting the opportunity to walk through and see everything firsthand was incredible. The transparency here is what separates the real players from the pretenders. Key Takeaway I can confirm that everything after the raws are done is 100% in-house in the USA. This isn't just slapping a "Made in USA" label on Chinese lyophilization. This is the real deal - actual USA compounding from FDA-regulated APIs. And They Went NUCLEAR for Black Friday 💣 Valor dropped their most aggressive pricing ever on USA-made peptides. Sale Highlights (Single Vials): 🔥 Retatrutide 10mg: $37.50 → $33.75 with code derek 🔥 Retatrutide 36mg: $99.99 → $89.99 with code derek 🆕 Cagrilintide 10mg - NOW IN STOCK: $75.99 → $68.39 with code derek 💪 Tesamorelin 10mg: $37.99 → $34.19 with code derek 💪 Tesamorelin 32mg: $110 → $99 with code derek ⚡ NAD+ 500mg - Back in Stock: $39.99 → $35.99 with code derek 🧬 Glow Blend (GHK-Cu + TB-500 + BPC-157): $55 → $49.50 with code derek 🧬 GHK-Cu/KPV Blend: $50 → $45 with code derek 🩹 BPC-157 20mg: $49.99 → $44.99 with code derek All prices include the extra 10% OFF with code derek Why This Matters: ✅ USA Compounded - From FDA-regulated APIs, not imported Chinese lyophilization ✅ ISO/IEC 17025:2017 Accredited Testing - Real standards ✅ Veteran-Owned ✅ >98% Purity Guaranteed ✅ Full Transparency - They let me film their facility ⏰ 48 HOURS ONLY Sale Ends: November 27th at 1pm EST Shop: https://valorpeptides.com/?ref=Derek