In the latest DDT Method podcast with @Anthony Castore , Anthony discussed NAD supplementation. What I found interesting is that Anthony seemed to be against NAD supplementation via NAD+ and its precursors if I understood correctly, and a more appropriate approach would be to instead use a combination of 5 amino and 1MNA. He suggested using 5 amino pre workout and 1MNA on rest days in the evening. Anthony - would you be able to expand on your thoughts regarding NAD supplementation given it seems like a given in the longevity community that you supplement with NAD+ (injection or IV) or its precursors (NMN, NR).

If you’ve ever watched a great coach or a great clinician work, you’ll notice something they don’t stare harder; they see differently. They aren’t simply looking for more data; they’re trying to understand the rhythm beneath the data. Biology, especially mitochondrial biology, is a dance long before it becomes a number on a lab report. This article is about learning to see that dance. To understand how SS-31, methylene blue, ketone esters, and even your training decisions interact with real cellular dynamics, you need to know one thing above all else: Biology doesn’t run on quantity, it runs on phase. This is the part that confuses even very smart people. We’re trained to think that oxidative stress = bad, antioxidants = good, more oxygen = good, more ATP = good. But life is rhythmic, not linear. Your mitochondria aren’t furnaces they’re oscillators. They need to pulse. They need to switch between states. They need to signal, respond, tighten, release, and tighten again. This is why a supplement, a peptide, or a drug can work beautifully in one phase of physiology and completely derail things in another. To understand this, we need to talk about one of the most underrated molecules in all of human physiology: cardiolipin. CARDIOLIPIN: THE CONDUCTOR OF THE MITOCHONDRIAL ORCHESTRA Cardiolipin is a special lipid that lives almost exclusively in the inner mitochondrial membrane. If the mitochondrial membrane were a concert hall, cardiolipin would be the acoustic paneling that allows the orchestra to play in tune. It has four fatty acid tails, which is extremely rare most lipids have two. That design allows it to shape the membrane into cristae, those elegant folds where electron transport happens. These folds aren’t random architecture; they control the spacing, alignment, and speed of electron flow. Without cardiolipin, the ETC complexes would be like a bunch of musicians sitting in the wrong seats. Even more importantly, cardiolipin is both a sensor and a switch. When it is oxidized in the right way, it helps signal adaptation. When it is oxidized in the wrong way, it collapses mitochondrial membrane potential, releases cytochrome c, and pushes the cell toward apoptosis. This is why tools that interact with cardiolipin like SS-31 are profoundly powerful but profoundly phase-dependent. They’re not like taking creatine or magnesium; they actively alter the structural language of the mitochondria.

I was watching a pod cast where the podcaster was talking about mega dosing this a couple times a year to get rid of senecese cells. Does anyone have experience with this or know if it is a real functional option. I just read an old article by Anthony o er on Chris Duffins endless evolution about layering Foxo4 Dri amd other peptides. Really enjoyed the article

This community exists to correct a problem I see every day: smart, motivated people making avoidable mistakes because they are reacting to information instead of reasoning through it. Everything here is built around clear thinking, proper sequencing, and confident restraint. There are several ways to engage. Each one is designed for a different level of responsibility. The question is not whether to invest. The question is where you are right now. The Cellular Intelligence Circle For Orientation, Context, and Staying Current The Circle is where confusion gets resolved before it turns into action. This is the right place if you want to: - Understand emerging science without overreacting to it - Learn how decisions are actually weighed - Separate signal from noise - Avoid unnecessary intervention It is a content-first environment designed to compound over time. Membership provides access to a growing, curated body of work that functions as a reference library, not a feed to keep up with. Inside the Circle: - Peptide of the Month (mechanism, context, restraint) - Protocol and case reasoning breakdowns - Science article reviews focused on interpretation, not hype - Monthly live Q and A - Periodic synthesis webinars The Circle is not coaching. It is not protocol delivery. It is where judgment is built. Pricing - $79 per month - $219 for three months - $499 for twelve months This level is appropriate when your primary goal is orientation, understanding, and staying sharp. One-Time Consultations For Specific Decisions. Consultations exist for moments when a decision needs to be handled correctly. They focus on: - Identifying what actually matters - Removing unnecessary complexity - Clarifying what not to do Pricing - One hour consultation: $350 - One hour consultation with follow-up: $500 This option makes sense when a single decision needs careful thought. Ongoing Advisory Core For Continuity and Guardrails. This is for people who no longer want to think through complex decisions in isolation.

This Retatrutide carbs vs no-carbs discussion is a perfect example of the kind of work we’ll be doing inside the Cellular Intelligence Circle. I am attaching a video so you guys can get a sense of what to expect. Not hot takes. Not protocols copied from the internet. Not arguing teams or tribes. Instead, I’ll show you how I actually think. How I zoom out, identify what system is really being affected, and trace decisions back to first principles like cellular energetics, redox balance, signaling hierarchy, and context. You’ll see how to move beyond surface-level debates and start asking better questions. The kind of questions that cut through hype, confusion, and false certainty. The goal of the Circle isn’t to tell you what to think. It’s to teach you how to think for yourself. If you’re tired of conflicting advice, overconfident influencers, and protocols that work in theory but fall apart in real humans, this community is built for you. We’ll break down topics like peptides, metabolism, training, recovery, fat loss, and longevity in a way that connects the dots instead of fragmenting them. We kick off in February, and each month will center around a focused agenda designed to build real understanding, not just information overload. Members will get long-form breakdowns, case studies, monthly live Q&A discussions, and practical frameworks they can actually apply. If this video made you stop and rethink the question instead of picking a side, you’re exactly who this was built for. More details coming soon…. The Cellular Intelligence Circle launches February.