Why Retatrutide Might Be The Answer To Your Weight Loss Plateau (The Glucagon Factor)
Alright, let’s talk about something I’ve been getting asked about constantly—plateaus. If you’ve been on sema or tirz and the scale just… stopped moving… you’re not alone. And no, you’re not doing anything wrong. I want to break down what makes retatrutide fundamentally different and why I think it’s going to change everything for people who’ve hit that wall. So Why Do We Actually Plateau? Here’s what’s happening in your body when weight loss stalls. Your body is smart. Too smart sometimes. When you start losing weight, it notices. And it doesn’t like it. Your metabolism slows down, your hunger hormones shift, and your body basically becomes this ultra-efficient machine trying to hold onto every calorie it can. This is called metabolic adaptation and it’s why pretty much every weight loss method eventually stops working as well. On sema, most people hit this wall around week 60. You’re cruising along, dropping weight, feeling great… then nothing. The scale doesn’t budge for weeks. It’s frustrating as hell. But it’s not you failing. It’s biology. Enter Glucagon: The Third Receptor Ok so here’s where it gets interesting. Semaglutide hits one receptor (GLP-1). Tirzepatide hits two (GLP-1 and GIP). Retatrutide hits three—GLP-1, GIP, AND the glucagon receptor. That third one is the game changer. And here’s why. In the phase 2 trials, people on retatrutide at the 12mg dose lost an average of 24.2% of their body weight over 48 weeks. But here’s the kicker—the weight loss curves showed NO plateau. They were still losing when the trial ended. The researchers straight up said a plateau hadn’t been reached yet. That’s wild. That basically never happens. What Glucagon Actually Does So what is this glucagon receptor doing that’s so special? It increases energy expenditure. Not just appetite suppression—actual increased calorie burn. Your body burns more at rest. It ramps up fat oxidation. Your liver starts breaking down stored fat for fuel instead of just sitting on it. Less fat creation, more fat burning.