🧬 Wednesday Medication Mic Drop: Why some weight-loss meds work better than others (and it’s not willpower) Not all weight-loss medications are created equal—and it’s not because people “try harder” on one versus another. Here’s the simplified landscape 👇 📉 Lowest average weight loss (≈3–7%) Orlistat 🧪 Works in the gut by blocking fat absorption ⚠️ Doesn’t affect hunger hormones or metabolism 🧠 Calorie loss without brain signaling = limited results and no patterned behavior change 💩 The unwanted side effect! no words needed here 📉📉 Moderate weight loss (≈5–10%) Phentermine 🧪 Sympathomimetic appetite suppression ⚠️ Raises heart rate, BP, stress signaling 🧠 Appetite suppression without metabolic repair isn’t sustainable 📉📉📉 Moderate–High (≈8–12%) Naltrexone/Bupropion (Contrave) 🧪 Dopamine + reward pathway modulation ⚠️ Works best for emotional/reward-driven eating 🧠 Behavior pathways matter—but biology still runs the show 📉📉📉📉 High (≈10–15%) Liraglutide (daily GLP-1) 🧪 GLP-1 receptor activation → insulin sensitivity + satiety ⚠️ Shorter half-life = more GI side effects for some 🧠 Hormone signaling beats appetite suppression 📉📉📉📉📉 Very high (≈15–22%+) Semaglutide / Tirzepatide (weekly GLP-1 / GIP-GLP-1) 🧪 Multi-pathway metabolic signaling: - Insulin sensitivity - Inflammation reduction - Kidney sodium handling - Vagal tone improvement 🧠 Ah-ha: These meds change gut brain communication, changes the way food signals the reward system and the metabolic environment, not just food intake 🔬 Why higher-ranked meds work better The more effective medications: - Signal to the brain - Improve insulin dynamics - Reduce inflammatory load - Support nervous system regulation Weight loss happens because the body finally feels safe enough to release energy. Which is why severe calorie restriction alone eventually stops working. ⚠️ Important truth most people miss If dosing is rushed or nutrition is ignored, even the most effective meds cause:

We are 1 week away from opening the course . The great part is , you have lifetime access to the ever-growing content. We will have a Calendly link available at the top of the course for easy access for scheduling our 1-on-1's Let's keep building out clinics with the right mindset in place... Most clinicians don’t quit medicine. They quit how medicine is practiced. When building clinics we want to start here—not with LLCs or logos—but with a question most people never slow down enough to ask: “What problem am I actually solving by building my own practice?” The moment that clicks, everything downstream gets easier: quality patient care, affordability and pricing, boundaries, marketing, preventing career burnout. If you’re here, chances are you already answered that question—maybe without words yet. That’s okay. This group exists to give language to instincts you already had. Comment the one thing you want to change in healthcare this year.

“Monday fatigue” doesn’t magically appear when your alarm goes off. It's usually preloaded on Sunday. Here’s the physiology behind it 👇 🧪 Your brain runs on prediction, by Sunday afternoon, your nervous system starts anticipating: - Early alarms - Cognitive demand - Social + work stress That anticipation increases cortisol and sympathetic tone before the week even starts. Now layer in what Sundays often include: - Later meals 🍝 - Alcohol 🍷 - Less sunlight ☀️ - Doom-scrolling + mental load 📱 Result? - Cortisol shifts later - Melatonin release is delayed - Sleep quality drops - Monday morning feels like jet lag—without the vacation 🛠️ How to fight Monday drag (without “being more disciplined”) These work because they shift timing, not because they add stress. 🌅 Anchor light early (even on weekends)10–15 minutes of outdoor light before 9am helps reset cortisol timing for Monday, not just Sunday. 🍽️ Pull dinner earlier on Sunday. Earlier meals = earlier insulin drop = earlier melatonin release. 🚶‍♀️ Low-stress movement Sunday afternoon. Walking > HIIT. This lowers sympathetic tone instead of adding to it. 🧠 Contain work thoughts. Write down Monday’s top 1–2 priorities BEFORE dinner. Your brain relaxes when uncertainty is reduced—this is neurobiology, not mindset fluff. ☕ Delay caffeine Monday morning (just a bit)Caffeine too early can worsen the cortisol crash later. Let your system wake itself first. 👉 Which one hits you hardest on Sundays? • Late sleep • Late meals • Anxiety/mental load • Weekend Alcohol •Something Else? or All of the above?

This discussion space is for paid DPC Launch Cohort members only. Content here focuses on business strategy, clinic-building frameworks, and peer collaboration for clinicians building or transitioning into Direct Primary Care models. and functional Medicine 👉 Patients and general community members: please use the main group feed for health & wellness content.

If your New Year’s resolution makes you tired just reading it… you already voted no and likely will not follow through. Every January we do the same thing: More goals. More rules. More pressure. And then we’re shocked when our hormones revolt by February. Here’s the science reality check: Your body doesn’t experience “ambition.” It experiences: - Cortisol spikes - Decision fatigue - Dopamine overload - Inflammatory noise So let's do something different this year!! Let's STOP doing something or take something off your plate this year! If it doesn't fulfill you stop doing it! 🧬 New Year’s Resolution: What are you doing LESS of? Let's remove the interference that gets in the way of goals! Why subtraction works: - Fewer daily decisions → lower cortisol + better insulin sensitivity - Less constant stimulation → dopamine receptors re-sensitize - Less stress input → nervous system exits survival mode - Less clutter → mitochondria actually do their job Translation: Your cells prefer calm consistency over heroic effort. Examples of powerful anti-resolutions: - Less late-night scrolling (your circadian rhythm says thank you) - Less over-explaining (your nervous system loves clean boundaries) - Less chasing every new wellness trend - Less reacting. More choosing. - less saying yes to additional tasks - less late night events - less daytime distractions 👉 What’s ONE thing you’re intentionally taking OFF your plate this year to support your hormones, metabolism, or nervous system? Drop it below. This year, subtraction is the strategy.