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Exploring Peptides Community

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6 contributions to Hacksmith's Free Peptalk Group
Best MOTS-C Dosage / Protocol?
This is probably the most common question I'm seeing now. What's the best dosage? How often for MOTS-C? Over in the paid community ($10/month), I have the explanation for this broken down in the Consolidated Reconstitution, Dosage, and Cycle Lengths Course. I actually have the protocols written out for all of the peptides. This is how it's written in that course: Common Dosages - Injectable: MOTS-C protocols can vary quite a bit in terms of dosages and frequency. People do anywhere from 0.5 to 5mg per injection. Ultimately, I think that starting on the low end to assess individual response, then increasing over time if needed is the best way to do it. If you can respond well at 0.5 mg and get what you need out of it, great. You saved money. Timing - Injectable: Because this typically gives energy, best time to take it is in the morning or pre-workout. It can be done either daily, every other day, or 5 days on 2 days off. So basically, starting low to assess effects does 1 of 2 things: 1. Let's you find an effective dosage 2. Saves you money Typically though, if someone is looking for the energy that it gives, they do it daily as that's how long the energy lasts for them. If they're looking for exercise performance increases, they may only take it on the days before a workout. But if looking for the metabolic benefits, increased insulin sensitivity, etc. then typically only a few times a week can be sufficient. Also, people say that they keep seeing a lot of varied protocols out there for this one. Well, this protocol covers it all. This post also explains the reasoning / justification behind the various frequencies. Now back outside to keep pressure washing and I'll be back in a bit if there are any questions!
1 like • 15d
Ty so much
Essential Supplements
Hey everyone! I added a guide to my website (have a few free ones on there) of some good essential vitamins to add along to your peptide stack. Here's the link: https://hacksmithspeptalk.com/resources/guides/supplements-that-pair-with-peptides
0 likes • 23d
So good. Ty
Apr 24 • 
Chat 💬
Retatrutide - Don't Get FOMO
Yesterday I asked a couple of questions about what people think the benefits of Retatrutide are that other GLPs don't give, as well as the specific benefits of the glucagon receptor component. Let's address those below, so you don't feel like you have FOMO if you don't use it instead of other GLPs. Disclaimer: I've used Reta for over 18 months. I love it. 1. The glucagon fat-burning benefit - Glucagon agonism can cause hepatic lipolysis (liver breaking down fat) and increasing energy expenditure. But guess what? Tirzepatide also reduces visceral fat significantly. Retatrutide doesn't reduce it but by maybe 8-10% more than Tirzepatide does. And the "fat-burning benefit" likely ends up being a maximum of 100-200 calories/day that it burns and is really going to exist at the higher dose. So "microdosing Reta with Tirz for fat-burning" likely isn't doing much for you. 2. Reduces / reverses fatty liver - Retatrutide is about 86% reduction of NAFLD, but Tirzepatide was somewhere around 60%. So yes, Retatrutide is really the best one on the market for this, but it isn't so significant that you have to use it over something like Tirzepatide in order to get this benefit. 3. Retatrutide prevents muscle loss / is muscle building - If you look at the DEXA data for Reta, about 80% of the weight loss is fat mass. But guess what? Tirz is about the same generally speaking. Now, Reta typically gives you less of a "feeling" of strong suppression, which lets you keep calories high, which means that protein is higher, which means that you can preserve more muscle. But ultimately, if you use a low enough dose of any GLP to where your appetite isn't completely crushed, then you'll be able to mitigate muscle loss. 4. Insulin resistance - Retatrutide definitely helps with insulin resistance. But the A1C reduction isn't quite as good as Tirzepatide's. So while it can be a great solution to fight against something like diabetes, it's likely not going to do it for you the way that Tirzepatide will.
0 likes • May 17
@Hack Smith where is the post on transitioning from one glp to another u mention in your stories today?
0 likes • May 17
@Hack Smith Ty ill check now
Topical Snap8 & GHKCU in HA Bottle
Hi, do I need to recon the ghkcu before adding to HA? I know I have to recon the snap8. Ty
0 likes • May 11
Thank you
May 6 • 
Chat 💬
Is this group dead?
Curious if this group is worth keeping around. Nobody really posts, etc. Before, the $10/mo group was too expensive. The Facebook was too suppressive. Now we have this, and it seems obsolete. Let me know!
1 like • May 6
Not dead! Im reading…will have questions soon but u already answered a few on ur IG stories the other day! Ty ur a wealth of knowledge!
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Linda H
1
1point to level up
@brenda-hernandez-3739
Here to learn about Peps!

Active 11h ago
Joined Apr 24, 2026
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