For those of us who’ve already been experimenting with retatrutide through research-grade sources, Eli Lilly’s new Phase 3 data is basically official validation. The mainstream is finally catching up to what early adopters have been experiencing in real time: this compound is on a completely different level from the standard GLP-1/GIP agonists. 📊 The Phase 3 Numbers Are Wild (But Honestly… Not Surprising) The TRIUMPH-4 late-stage clinical trial showed: - ~28.7% average weight reduction over 68 weeks - Over 70 lbs lost on average at the highest dose - Almost 40% of participants dropped 30%+ of their total body weight - Significant improvements in knee osteoarthritis pain and functional mobility For anyone who's used retatrutide consistently, this lines up with lived experience:more aggressive fat loss, faster, and with a metabolic “drive state” you don’t get from GLP-1s alone. 🔬 Why It Outperforms GLP-1s Retatrutide is a triple agonist — GLP-1 + GIP + glucagon.This multi-pathway activation is what biohackers have been calling the “holy trinity” of metabolic modulation: - GLP-1 = appetite suppression + slower gastric emptying - GIP = enhanced insulin response + energy partitioning - Glucagon = increased fat oxidation + metabolic acceleration When all three are firing, you get that stacked effect that feels very different from semaglutide or tirzepatide. ⚠️ Side Effects & Tolerability (From Both Trial and Real-World Use) Lilly’s data highlights the same things many of us have seen firsthand: - Nausea, diarrhea, and early-cycle GI turbulence - A subset of users tapping out due to side effects - Some stopping because the weight loss was “too much, too fast” Nothing shocking — but definitely a reminder that dose ramping is everything with this compound. 📅 What’s Coming Next More Phase 3 readouts will continue through 2026, but if these results hold, retatrutide is going to completely reshape the metabolic-therapeutics landscape.

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