Aug 27 • GLP-1 & PEPTIDE TALK
PEPTIDE SPOTLIGHT: TESAMORELIN
Let’s talk about one that gets a LOT of attention when the conversation turns to body composition, visceral fat, recovery and growth hormone. 👀🔥
💉 WHAT IS TESAMORELIN?
Tesamorelin is a peptide that mimics GHRH (growth hormone-releasing hormone), one of the signals your body naturally uses to tell the pituitary gland to release growth hormone.
Think of the pathway like this:
Tesamorelin → Pituitary → Growth Hormone (GH) → IGF-1
Instead of supplying growth hormone directly, Tesamorelin stimulates the body's own GH pathway.
🔥 WHY DOES EVERYONE TALK ABOUT BELLY FAT?
This is probably what Tesamorelin is best known for.
Research has shown that Tesamorelin can reduce visceral adipose tissue, the deeper abdominal fat that surrounds the organs.
And this is an important distinction:
We're talking about visceral fat, not necessarily the soft, pinchable fat directly underneath the skin.
That's why you hear Tesamorelin discussed so often around waist circumference and body composition.
✨ WHAT ELSE IS IT BEING STUDIED FOR?
🔥 Visceral Fat
Its effects on abdominal visceral fat are one of the most researched aspects of Tesamorelin.
💪 Body Composition
Because it influences the GH/IGF-1 pathway, researchers have also looked at changes in lean body mass and overall body composition.
😴 Recovery
Growth hormone is involved in tissue repair and recovery throughout the body.
🧬 GH + IGF-1
Tesamorelin stimulates natural GH secretion, which in turn increases IGF-1.
⚡ Metabolism
The GH pathway plays a role in how our bodies use and store energy, including the breakdown of fat.
🤔 TESAMORELIN VS. CJC-1295
These two get compared a lot because they both work through the GHRH pathway.
Both essentially encourage the pituitary to release more of your body's own growth hormone, but they're different peptides with different structures, pharmacology and research behind them.
So although they're often discussed for similar goals, they're not interchangeable.
❤️ WHY I FIND THIS ONE INTERESTING
We hear "belly fat" all the time, but not all abdominal fat is the same.
There's the subcutaneous fat we can pinch and then there's visceral fat deeper inside the abdomen surrounding our organs.
Tesamorelin is especially interesting because its research has demonstrated reductions in that deeper visceral abdominal fat.
Another reminder that body composition is about SO much more than the number on the scale. 🙌
✨ For education and discussion only. This isn't medical advice.
💬 Had you heard of Tesamorelin before?
Should we do Ipamorelin next and then break down why people talk about combining different GH-pathway peptides? 👀
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PEPTIDE SPOTLIGHT: TESAMORELIN
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