New Article on X about Unlocking Longevity at the Cellular Level https://x.com/startmyresearch/status/2062350509680267394

I've seen alot of posts lately about injectable SLU-PP-332...specifically the DMSO-based solutions floating around. I want to address this directly because I think it's important for anyone in this community doing serious research. The short answer: injectable SLU-PP-332 in DMSO is a bad idea, and here's why. The Formulation Problem SLU-PP-332 is a moderately lipophilic small molecule (MW ~290 Da). DMSO can dissolve it in the vial just fine — but the moment you inject it, it hits aqueous interstitial fluid and the whole game changes. You get rapid dilution, potential supersaturation, and microcrystal formation. Those crystals can lodge in capillaries and tissue, causing sterile inflammation, granulomas, or worse if someone is foolish enough to go IV. This isn't theoretical. Lipophilic compounds without proper solubilizing excipients, think cyclodextrins, surfactants, lipid nanoparticles, PEG/Tween blends, routinely precipitate post-injection. The published preclinical work (Billon et al., 2023/2024) used carefully controlled pharmaceutical-grade vehicles for IP injection in rodents. Nobody is doing that with gray-market DMSO solutions. There's No Validated Injectable Protocol Zero published literature exists on IM, SC, or IV formulations in humans. That means: - Unknown safe injection volume and site - Unknown local tissue tolerance (pain, necrosis risk) - Unknown systemic PK when first-pass metabolism is bypassed - No human safety data - none The published rodent studies used intraperitoneal injection with pharmaceutical vehicles. That's a long way from someone pinning a DMSO solution subcutaneously. Bypassing First-Pass May Actually Be a Problem SLU-PP-332 likely undergoes CYP450 hepatic metabolism — the specific pathways aren't fully characterized yet, but that first-pass filtering is probably doing something useful. Bypass it with injection and you're potentially spiking parent drug concentrations into territory with zero dose-response data to guide you.

Has anyone tried Selank and Semax versus N-Acetyl Selank Amidate and N-Acetyl Semax Amidate? Curious as to what you thought was better..