Your Balls on Testosterone: The ScienceâBacked Peptide Fix
The Best Peptides for Preserving Fertility on TRT (substack post here - https://open.substack.com/pub/prml/p/your-balls-on-testosterone-the-sciencebacked?r=eiljo&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true) Testosterone Replacement Therapy (TRT) does wonders for energy, mood, and muscle â but thereâs a catch: **it shuts down the brainâtesticle conversation that keeps sperm production alive**. When exogenous testosterone enters the bloodstream, the brain stops producing gonadotropinâreleasing hormone (GnRH). That drop silences luteinizing hormone (LH) and follicleâstimulating hormone (FSH), causing testicular shrinkage, low sperm counts, and infertility.[1][2] The solution isnât to abandon TRT â itâs to *biohack the communication loop* with the right peptide support. hCG: The Clinically Proven Workhorse: Human chorionic gonadotropin (hCG) has long been the goâto fertility safeguard for TRT users. It **acts as an LH mimic**, directly telling the Leydig cells in your testes to keep producing testosterone and sperm. - Men who stack TRT with lowâdose hCG (250â500 IU, 2â3x per week) typically **maintain testicular volume, ejaculate consistency, and fertility window** â even while fully suppressed by external T.[3][2][1] For men planning to father children, no peptide has more clinical mileage than hCG. Itâs been used in fertility clinics for decades and is still considered the **gold standard for preserving sperm health on TRT**. Kisspeptinâ10: The Upstream Innovator: Enter **Kisspeptinâ10**, the rising neuropeptide challenger. - Unlike hCG, which works *downstream*, kisspeptin activates the *top* of the reproductive axis â stimulating the hypothalamus to release natural GnRH, which triggers FSH and LH pulses that restore proper rhythm to the entire system.[4][5][6]