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A lot of people researching with Tesamorelin, CJC-1295, or Ipamorelin underestimate how much timing impacts their results — especially if they’re also on a GLP-1 like semaglutide or tirzepatide, or retatrutide. This could be destroying your research if implemented wrong. Here’s why this actually matters 👇 ⚙️ 1. GH Secretagogues Rely on Low Insulin to Work These compounds trigger your pituitary to release growth hormone (GH) — but only if your body’s “environment” allows it. When you eat (especially carbs or protein): - Insulin spikes - GH release drops by up to 90% - The entire “pulse” these peptides are designed to create is flattened So, if you inject right after eating, you’re basically wasting part of the dose. 🩸 2. Food Still in Your System = Suppressed GH Even if you haven’t eaten for a bit, your body might still be digesting — especially if the meal was higher in fat or protein. That means: - Insulin is still elevated - Blood glucose hasn’t fully normalized - Your GH pulse is still blunted That’s why a true fasted state (not just “I haven’t eaten in an hour”) is essential. 🧬 3. GLP-1s Make This Even More Critical If you’re on a GLP-1 agonist, this becomes even more important. Here’s why: - GLP-1s slow gastric emptying, meaning food digests much slower. - Even when it’s been hours since you’ve eaten, insulin can still be elevated. - That lingering insulin keeps GH suppressed — even though you feel fasted. In short: GLP-1s make your “fasted” window longer — so you need to adjust your timing. ⏰ 4. How to Time It for Best Results ☀️Morning Protocol - Research right after waking (no food or coffee yet) - Wait 30–45 minutes before eating 🌙 Night Protocol - Wait 1–2 hours after your last meal before researching - If you’re on a GLP-1, extend that to 2–3 hours after eating - After researching, wait 30–45 minutes before eating or sleeping 💡 These windows give insulin time to normalize so your GH pulse isn’t blocked.