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13h • Peptide Tips
⚡ Why You Need to Be Fasted for GH Secretagogues — and Why It’s Even More Critical on GLP-1s
A lot of people researching with Tesamorelin, CJC-1295, or Ipamorelin underestimate how much timing impacts their results — especially if they’re also on a GLP-1 like semaglutide or tirzepatide, or retatrutide. This could be destroying your research if implemented wrong.
Here’s why this actually matters 👇
⚙️ 1. GH Secretagogues Rely on Low Insulin to Work
These compounds trigger your pituitary to release growth hormone (GH) — but only if your body’s “environment” allows it.
When you eat (especially carbs or protein):
- Insulin spikes
- GH release drops by up to 90%
- The entire “pulse” these peptides are designed to create is flattened
So, if you inject right after eating, you’re basically wasting part of the dose.
🩸 2. Food Still in Your System = Suppressed GH
Even if you haven’t eaten for a bit, your body might still be digesting — especially if the meal was higher in fat or protein.
That means:
- Insulin is still elevated
- Blood glucose hasn’t fully normalized
- Your GH pulse is still blunted
That’s why a true fasted state (not just “I haven’t eaten in an hour”) is essential.
🧬 3. GLP-1s Make This Even More Critical
If you’re on a GLP-1 agonist, this becomes even more important.
Here’s why:
- GLP-1s slow gastric emptying, meaning food digests much slower.
- Even when it’s been hours since you’ve eaten, insulin can still be elevated.
- That lingering insulin keeps GH suppressed — even though you feel fasted.
In short:
GLP-1s make your “fasted” window longer — so you need to adjust your timing.
⏰ 4. How to Time It for Best Results
☀️Morning Protocol
- Research right after waking (no food or coffee yet)
- Wait 30–45 minutes before eating
🌙 Night Protocol
- Wait 1–2 hours after your last meal before researching
- If you’re on a GLP-1, extend that to 2–3 hours after eating
- After researching, wait 30–45 minutes before eating or sleeping
💡 These windows give insulin time to normalize so your GH pulse isn’t blocked.
⚡ 5. Why It Matters
When you’re fully fasted:
- GH pulse = stronger and cleaner
- IGF-1 levels = higher over time
- Fat loss, recovery, and sleep benefits = significantly better
When not fasted:
- GH pulse = weak
- IGF-1 barely moves
- Results = inconsistent and underwhelming
🧠 Quick Recap
- ✅ Eat → insulin ↑ → GH ↓
- ✅ GLP-1s slow digestion, keeping insulin up longer
- ✅ Wait 1–2 hours fasted (or 2–3 hours on a GLP-1) before injecting
- ✅ Wait 30–45 minutes after injecting before eating
- ✅ Timing = everything if you care about results
This is one of the things that I see constantly overlooked, and I haven't seen anyone talk about so, so I hope it helps.
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⚡ Why You Need to Be Fasted for GH Secretagogues — and Why It’s Even More Critical on GLP-1s
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