Here's something that surprises a lot of people: splitting your peptide doses based on half-life can dramatically improve your results with the SAME total amount. I've been seeing these questions come up lately so, I thought I would make an entire post to cover it. It's All About Half-Lives Every peptide has a half-life - the time it takes for half the medication to clear your system. This determines how stable your blood levels stay: - Short half-life peptides (hours): Think BPC-157, TB-500, many growth hormone peptides - Medium half-life peptides (1-3 days): Some modified versions - Long half-life peptides (4-7 days): GLP-1s like Semaglutide, Tirzepatide The Problem with Ignoring Half-Lives Dose a short half-life peptide once daily? You're getting massive peaks and deep valleys. Your levels might drop to near-zero before your next dose. Dose a long half-life peptide once weekly? You get a huge spike, then a slow decline over 7 days - still a roller coaster, just stretched out. The Split Dosing Advantage Match your dosing frequency to the half-life, and suddenly those peaks and valleys flatten out. Your peptide levels stay in the therapeutic sweet spot consistently. The result? People commonly report: - Better overall effects from the same total dose - Fewer side effects (less intensity at peak levels) - More consistent results throughout the week - Less "wearing off" between doses Real Examples: GLP-1s (long half-life): Split weekly into 2-3x per week = more stable appetite control, less nausea Short half-life peptides: Dose 2-3x daily instead of once = sustained therapeutic levels vs. brief spikes "But why don't doctors prescribe it this way?" Simple: adherence and convenience. - Patients coming to clinics need easy scheduling - Simpler protocols = better compliance - Less frequent = less intimidating for needle-shy patients - Pharmaceutical companies dose for the average patient But if you're self-administering and want to optimize? You can dial in YOUR protocol based on pharmacokinetics.

Is Simple Peptides the only company that compounds and tests in the USA? Are there other companies on the list that are USA-based?