Split Dosing Peptides: Understanding Half-Lives for Better Results 🎢

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Here's something that surprises a lot of people: splitting your peptide doses based on half-life can dramatically improve your results with the SAME total amount. I've been seeing these questions come up lately so, I thought I would make an entire post to cover it.

It's All About Half-Lives

Every peptide has a half-life - the time it takes for half the medication to clear your system. This determines how stable your blood levels stay:

Short half-life peptides (hours): Think BPC-157, TB-500, many growth hormone peptides
Medium half-life peptides (1-3 days): Some modified versions
Long half-life peptides (4-7 days): GLP-1s like Semaglutide, Tirzepatide

The Problem with Ignoring Half-Lives

Dose a short half-life peptide once daily?

You're getting massive peaks and deep valleys. Your levels might drop to near-zero before your next dose.

Dose a long half-life peptide once weekly?

You get a huge spike, then a slow decline over 7 days - still a roller coaster, just stretched out.

The Split Dosing Advantage

Match your dosing frequency to the half-life, and suddenly those peaks and valleys flatten out. Your peptide levels stay in the therapeutic sweet spot consistently.

The result? People commonly report:

Better overall effects from the same total dose
Fewer side effects (less intensity at peak levels)
More consistent results throughout the week
Less "wearing off" between doses

Real Examples:

GLP-1s (long half-life): Split weekly into 2-3x per week = more stable appetite control, less nausea

Short half-life peptides: Dose 2-3x daily instead of once = sustained therapeutic levels vs. brief spikes

"But why don't doctors prescribe it this way?"

Simple: adherence and convenience.

Patients coming to clinics need easy scheduling
Simpler protocols = better compliance
Less frequent = less intimidating for needle-shy patients
Pharmaceutical companies dose for the average patient

But if you're self-administering and want to optimize? You can dial in YOUR protocol based on pharmacokinetics.

Bottom Line:

The half-life tells you the story. More frequent dosing matched to shorter half-lives = more stable blood levels = often significantly better results with the same total dose.

Understanding this one concept can be the difference between "meh" results and "wow, this actually works."

Example check out the plots below:

Plot 1 showing 8 mg 1x per week

Plot 2 shows 2mg every other day

You will notice how much more stable levels are on plot 2 and that's the whole idea behind it.

What's your experience with split dosing? Have you noticed better results with more frequent administration? 👇

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