21d • General discussion
Peptide of the Day: Semax
CATEGORY
Cognitive / Neuroprotective
WHAT IT IS
Semax is a synthetic peptide derived from ACTH (4–10). It was developed for cognitive enhancement and neurological protection and has been used clinically in parts of Eastern Europe.
WHAT IT DOES
• Enhances focus and mental clarity
• Improves learning and memory
• Supports mood and motivation
• Promotes neuroplasticity via BDNF signaling
• Helps protect brain tissue under stress
HOW IT WORKS
• Modulates melanocortin receptors
• Increases BDNF and TrkB activity
• Influences dopamine and serotonin pathways
• Reduces neuroinflammation and oxidative stress
COMMON USE CASES
• Brain fog
• Focus and productivity
• Learning and retention
• Neurological recovery
• Mental fatigue and burnout
ADMINISTRATION
Intranasal delivery is most common due to direct CNS access and rapid onset.
TYPICAL RESEARCH DOSING
300–600 mcg per day
Often split into 2–3 doses
HOW IT FEELS (USER-REPORTED)
• Clearer thinking
• Faster recall
• Increased motivation
• Calm but focused mental state
COMPARE
Semax → focus-forward and stimulating
Selank → calming and anxiolytic
NOTES
Semax does not act like a stimulant. Effects are often described as clean mental clarity rather than jittery energy.
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Peptide of the Day: Semax
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