Why does muscle glycogen depletion become limiting during prolonged, moderate-intensity endurance activities?
A. Glycogen is toxic to muscle cells when concentrated
B. Glycogen cannot be oxidized without simultaneous fat oxidation
C. Glycogen stores are finite (~300-400 g total), and carbohydrate oxidation is the primary fuel source at this intensity
Answer in the poll, then explain your rationale below in the comments! I'll follow up with my breakdown of the question after enough people have responded.
From Chapter Chapter 3: Bioenergetics of Exercise and Training
DCO Code: 1.E2
NOTE: Image is for illustration purposes, not needed to answer the question.