A Clear, Science-Based Look at a Potent Semi-Synthetic Compound Misrepresented as “Kratom” Mitragynine pseudoindoxyl — often called MP or “pseudo” — is not part of the natural kratom leaf. It’s a semi-synthetic, highly potent opioid-like compound that has entered the marketplace through adulterated products misbranded as “kratom.” Scientists have been studying MP for its unusual pharmacology, its powerful receptor activity, and its implications for both drug development and public health. Regulators are paying attention for very different reasons: MP is potent, it’s unregulated, and in many cases it’s being sold as kratom when it is not kratom at all. Let’s break down exactly what it is — and what consumers, advocates, and policymakers need to know. 🔬 Is Mitragynine Pseudoindoxyl Found Naturally in Kratom? No. Scientific literature is crystal clear on this point: ✔ Mitragynine pseudoindoxyl is not found in natural Mitragyna speciosa leaf. - It does not appear in fresh or dried kratom leaves. - It is considered a semi-synthetic compound, an oxidative rearrangement product, or a metabolite formed after consumption, not a native plant alkaloid. Evidence:A widely cited metabolism study (Kamble et al., 2020) confirmed that MP is formed in human plasma after 7-hydroxymitragynine is metabolized, not inside the plant.➜ https://pmc.ncbi.nlm.nih.gov/articles/PMC7737207 Another medicinal-chemistry paper confirms MP was absent from all natural leaf samples analyzed.➜ https://pubmed.ncbi.nlm.nih.gov/37332089 This distinction matters. MP’s presence in a commercial product typically means chemical manipulation, not traditional kratom. 🌿 Understanding the Difference: Natural vs. Semi-Synthetic Alkaloids Here is the clean breakdown your customers and policymakers need: 1. Mitragynine (MG) - The primary natural alkaloid in kratom. - Usually 60–70% of total alkaloid content. - Functions as a partial opioid receptor agonist, but with a broad, multi-receptor profile.

I'm sharing my recent bloodwork metabolic panel results. I get numerous questions about how natural kratom can affect bloodwork and health in general. I've been a daily kratom consumer since 2016. I use roughly 5 grams 4 times per day. I use my tested kratom and do not purchase anywhere else. Making sure that you are consuming clean kratom is very important. There are heavy metals and specific areas that should not be harvested from. I am also including a link to my heavy metals hair test from earlier this year. https://christophersorganicbotanicals.com/clean-living-htma-test-heavy-metals-in-kratom/

A Modern Epidemic That Won’t Let Go Opioid Use Disorder (OUD) has become one of the most devastating public health crises in America. Millions of people struggle with addiction to prescription painkillers, heroin, and fentanyl, powerful opioids that hijack the brain’s reward system and tear apart lives. The rise of Opioid Use Disorder has made headlines, underlining the urgency for effective solutions. Understanding the complexities of Opioid Use Disorder is essential for developing effective treatments. The ongoing challenge of Opioid Use Disorder demands innovative solutions that consider patient needs. The statistics paint a grim picture: around 11 million Americans misuse opioids every year, 5.6 million live with OUD, and nearly 80,000 die from overdoses annually. The COVID-19 pandemic only deepened the crisis, isolating people while fentanyl, a synthetic opioid up to 100 times stronger than morphine, flooded the market. Despite decades of effort, treatment options remain limited. Medications like methadone and buprenorphine help, but many patients still face barriers like stigma, restricted access, and relapse. Clearly, a new approach is needed. Nature’s Blueprint: What Kratom Reveals About Balance Researchers are continually exploring how kratom can aid in alleviating symptoms of Opioid Use Disorder. For centuries, people in Southeast Asia have used Mitragyna speciosa, known as kratom, to manage pain, fatigue, and withdrawal. The plant’s active compounds, mitragynine and 7-hydroxymitragynine (7-OH), interact with the same opioid receptors that prescription painkillers target. Many are hopeful that the insights from kratom research will lead to better management of Opioid Use Disorder. The difference is that kratom’s effects are less intense and more balanced, especially when consumed as whole-leaf tea. However, when isolated or concentrated, 7-OH can show traditional opioid-like properties such as tolerance, dependence, and reinforcement. This is why natural kratom must be understood in its full-leaf context, not through synthetic manipulation.

December 14, 2022 Red Bubble Kratom is yet another easy and effective way to enjoy the most loved herb – Mitragyna specosia. Every year that passes, new ways to ingest organic plants emerge. So when there are so many ways, why settle for one? Kratom extraction refers to the process of obtaining the active compounds present in organic tree leaves (Mitragynine), particularly Mitragyna, for consumption. This method is relatively new and gaining popularity among enthusiasts of Mitragyna, also known as kratom. Extraction techniques involve isolating desired components from Mitragyna leaves, such as alkaloids and flavonoids, using methods such as solvent extraction or steam distillation. These techniques aim to enhance potency and consistency compared to consuming raw leaves. Extracts offer greater control over dosage and consumption method, available in various forms, such as powders or liquids. They can also mitigate undesirable aspects associated with raw leaves, such as digestive discomfort. However, the long-term effects and safety of extraction are still being studied, emphasizing the need for responsible use. Overall, extraction provides a more potent and controlled way to ingest mitragyna, with growing interest as research continues. Use Kratom responsibly, follow dosages, and consult a healthcare professional if you have health concerns or take medications. Kratom extracts are available in all Mitragyna stores, both online and offline. However, you don’t always have to contact a kratom store near you. Customers can now make kratom extract at home. It is called the Red Bubble Kratom method. The kratom is frozen with water in the kratom red bubble extraction procedure. The color Red is created when these two objects are frozen together, therefore the name. We are aware that you have come to learn how to make it and the science underlying this technique.

December 17, 2022 You may be a natural Kratom user (or at least you should be), but the tree’s leaves may or may not make you feel better. One reason might be that to produce strong results, you will need many herbs. However, it can lead to side effects like nausea, constipation, sweating, etc., and create a tolerance to Ketum. To make your botanical potent enough to maintain moderate doses, you can use natural potentiators that enhance your experience. Using Kratom potentiators can surely double the benefits of this all-natural herbal plant. Some may ask the question. How to make kratom stronger? The 10 Best Kratom Potentiators There is quite a large list of Kratom potentiators that can make your botanical super strong. However, we’ll be discussing 10 of the best Kratom potentiators to give you an insight into making your Ketum super potent: 1. Watercress - Watercress, once thought only to be a decorative item, is now gaining popularity as a nutritious Kratom potentiator. This moist lettuce significantly amplifies the effects of the herb. It is a highly effective natural meal that enhances the effects of Mitragyna. - Many people are unaware that watercress contains more iron than spinach and more vitamin C than oranges. Watercress inhibits the CYP450 enzyme as well. As a result, the strength and duration of the herb’s effects may be enhanced. 2. Freezing Kratom - One of the best ways to strengthen and improve your Kratom is to freeze it. First, soak your plant in water. You can simmer it for a few minutes if you want, but it’s not necessary. After that, shake it and place it in the freezer. - The goal of freezing is to allow the cell walls of the plants to rupture. Within the cell walls are the kratom alkaloids. The plant’s cell walls are broken down, making it more accessible and powerful. Because there is no chance of a chemical reaction, you only use water for freezing.