14d • General discussion
You're handed this dataset. What's your first question?
You are handed a scenario, not a real dataset. I am sure this type of brief has landed in your inboxes:
"Here's RNA-seq from 40 tumour samples and 40 matched normal tissue. Samples were collected over 8 months across two clinical sites. Build a classifier."
Before any modelling: what's the first question you'd ask the person who handed you this?
Reply with your one question. I'll pull the most common threads in a follow-up post and run through what the methods section would need to say for each one to be answerable, the way I'd flag it in an editorial review.
(No wrong answers here. The ones that name a specific confound, site, batch, collection date, will probably crowd the leaderboard.)
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You're handed this dataset. What's your first question?
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