Jun 20 • General discussion
Thank you for being part of Journal Club No. 03.
Whether you tuned in live, dropped a question in chat, or are catching the recording now, thank you for spending part of your Saturday reading a real paper with us.
We covered a lot of ground. Cas13, the RNA-targeting member of the CRISPR family. Where and how it actually cuts, mapped down to the single nucleotide. Why its collateral cleavage, the part that looked like a flaw, is the exact mechanism behind rapid diagnostic tests. And RNA segment editing, a new tool built from all of that, including a proof of concept on a Huntington's disease RNA.
If you have a question that did not make it into the live chat, drop it below. I will work through everything posted here over the course of the week.
The full paper is linked below if you want to read it yourself. It is open access.
Lam et al. (2026), Molecular basis of target RNA cleavage by Cas13, Nature Communications.DOI: 10.1038/s41467-026-71578-7
Journal Club No. 04 is already picked. We are reading Sang and colleagues, a 2026 paper on a molecular glue complex breaking down, and how that drives resistance to RAS inhibitor drugs in cancer. If you work anywhere near oncology, drug resistance, or targeted therapy, this one is worth being in the room for.
See you at the next one.
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Thank you for being part of Journal Club No. 03.
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