Jun 6 • General discussion
Journal Club #1
Hi all,
Thank you all for joining the Journal Club today!
Here is the link for the paper we discussed today: Deng P, Lee H, Armijo C, Wang H, Gao A. Protein-templated synthesis of dinucleotide repeat DNA by an antiphage reverse transcriptase. Science. 2026 Apr 16:eaed1656. https://www.science.org/doi/abs/10.1126/science.aed1656?casa_token=o4kje3zWIbgAAAAA:qg0r4vb9WidUJlIegAoitY_Pj9i2xLFau4Ng9B47yZQaalqt_k37HjcZckF1Zh1iAfAI-JRJrL5OP8k&casa_token=e4KgmYrgeVUAAAAA:R1eNZEttruXuE-bC9yFeOBoQKO2Of2gaFsps5RkSgY_LaakPNVyvg8QT35KvUH2HatYMZKPuTlAZdF8
References:
- Gao L, Altae-Tran H, Böhning F, Makarova KS, Segel M, Schmid-Burgk JL, Koob J, Wolf YI, Koonin EV, Zhang F. Diverse enzymatic activities mediate antiviral immunity in prokaryotes. Science. 2020 Aug 28;369(6507):1077-84.
- Wilkinson, M.E., Li, D., Gao, A., Macrae, R.K. and Zhang, F., 2024. Phage-triggered reverse transcription assembles a toxic repetitive gene from a noncoding RNA. Science, 386(6717), p.eadq3977.
- Tang S, Conte V, Zhang DJ, Žedaveinytė R, Lampe GD, Wiegand T, Tang LC, Wang M, Walker MW, George JT, Berchowitz LE. De novo gene synthesis by an antiviral reverse transcriptase. Science. 2024 Aug 8;386(6717):eadq0876.
Feel free to add any comments or questions you might have!
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Journal Club #1
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