Research shows… What makes this study so critical is that they used DEXA scans to measure exactly how much of the weight lost was fat, and how much was muscle. If you’ve ever dieted hard and watched your muscles deflate, you know this is the million-dollar question in the world of weight loss. The control group included people on dulaglutide (a GLP-1–only drug) and a placebo, so we could see how retatrutide really stacks up. The Results So, what did they find? At 36 weeks, participants taking 8 mg of retatrutide lost, on average, a staggering 26.1% of their total fat mass (via DEXA). This was pure fat. And remember, these people are changing NOTHING about their daily lives (other than just eating less because of the effects of the drug). The lean mass (“muscle”) loss was approximately 20–40% of the total weight lost, meaning that a solid 60–80% of the weight loss was actual fat, not lean tissue. For comparison, the control group (on dulaglutide or placebo) lost just a fraction of that. Placebo lost approximately –4.5% of their fat mass, while dulaglutide lost about –2.6%. Retatrutide produced the largest absolute fat loss ever recorded in an obesity/diabetes drug trial. And it did so with about the same lean mass preservation as the “best” current drugs. Fat vs Muscle Every time you lose weight, even with the “miracle” GLP-1 drugs, some of it is going to be muscle, not just fat. The proportion matters. Losing too much muscle can tank your metabolism, weaken your strength, and set you up for a rebound. Lose mostly fat, and you preserve your engine for the long run. This 2025 DEXA study shows that the ratio of fat-to-muscle loss is basically the same as you’d get with tirzepatide or semaglutide, but you get way more total fat loss. In other words, retatrutide supercharges the process without making the muscle loss any worse. This is a game-changer, especially for anyone who wants to look, feel, and perform at their best.

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