Quick Answer Brenipatide (LY3537031) is an investigational once-monthly injectable dual GLP-1 and GIP receptor agonist currently being developed by Eli Lilly, the company behind Retatrutide. Unlike most GLP-based compounds currently in development, Brenipatide is being investigated not only for obesity and metabolic health but also for alcohol use disorder, tobacco use disorder, opioid use disorder, major depressive disorder, bipolar disorder, schizophrenia, irritable bowel syndrome, and asthma. Its broad clinical development program suggests that scientists are increasingly viewing GLP-based medicines as much more than appetite-suppressing compounds. Orion Peptides Discount Code Interested in premium research peptides? Orion Peptides offers third-party tested research compounds with purity testing on every batch. Use discount code PARKER15 for 15% OFF your order. The Future of GLPs May Have Nothing to Do With Weight Loss When most people hear the words GLP-1 agonist, they immediately think of one thing—weight loss. That's understandable. Over the past several years, compounds like Semaglutide, Tirzepatide, and Retatrutide have completely changed how scientists think about obesity and metabolic disease. However, something interesting has happened along the way. Researchers began noticing that these compounds appeared to influence far more than appetite alone. People reported drinking less alcohol. Others stopped smoking. Food noise disappeared almost overnight for some individuals, while scientists began asking whether these compounds could influence reward pathways found throughout the brain. Today, researchers are asking a much bigger question: Are GLP-based medicines actually metabolic drugs, brain-health drugs, or perhaps both? That question may help explain why Eli Lilly is currently developing Brenipatide (LY3537031). Unlike Retatrutide, Brenipatide isn't a triple agonist and it isn't designed to replace existing weekly GLP medications. Instead, Lilly appears to be taking a completely different approach—one that could ultimately reshape how we think about this entire class of medicines.