@Tony Huge "restores the brain-testes signaling (LH and FSH)" It might be important to some to know how Enclomiphene restores the signaling Enclomiphene blocks estrogen receptors in the brain My interpretation is that; Enclomiphene blocks the estrogen receptors making your body think it needs more Estrogen. The body uses LH & FSH to make Testosterone, so Testosterone can be aromatized into Estrogen. The body is ultimately trying to create more Estrogen because the receptors are blocked and it thinks it needs more Estrogen Enclomiphene has nearly doubled Testosterone for me, but also nearly doubled Estrogen as well. I didn't have any high estrogen side effects, so I didn't jump on an aromatization inhibitor. I did start taking DIM (Diindolylmethane) and Calcium D-Glucarate. I have another biomarker test coming up to see how my levels are working out. - DIM (Diindolylmethane) — supports phase I estrogen metabolism, shifting estradiol toward less proliferative metabolites. This is probably the single most impactful supplement for your situation - Calcium D-Glucarate — supports phase II estrogen detox by inhibiting beta-glucuronidase, preventing estrogen from being reabsorbed in the gut AI= Enclomiphene is a selective estrogen receptor modulator (SERM) that primarily targets estrogen receptors in the hypothalamus and pituitary gland. Normally, estrogen binds to these receptors and signals the brain to reduce the production of gonadotropin-releasing hormone (GnRH), which in turn lowers the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). By blocking estrogen from binding, enclomiphene “tricks” the brain into perceiving low estrogen levels, prompting the hypothalamus to release more GnRH. This stimulates the pituitary gland to increase LH and FSH production.

Mr. Reed, I can't thank you enough I am going to use your list as reference points when I speak with the genetic counselor I ended up getting an appointment with one

Top notch advice. I appreciate the time and effort everyone (Aaron Reed, Dan Hybrid, and others) has put in to help this community and myself. Y'alls experience and expertise is highly valued I have been on the genome sequencing kick for several years now. As cheap as it is, I figure it is worth having the information for my own piece of mind and long-term planning. I have just run into my own learning curve with it, and it has eluded the top of my list I have not been truly worried about the out-of-range results. Finding what is good and bad is the reason for testing From the little research I have done, I think I have a plan with dropping the Boron supplement and taking the DIM (200mg) and Calcium D-Glucarate (500mg x2) supplements I am kind of just running everything by the group to make sure I am on the right track. There are a lot of folks in here that know what they are doing. I am not one of them. I have the "Google" and it is only worth what I have paid for it - Nothing Again, thank you

I honestly never expected to get this level of quality advice on the forum. I owe someone a co-pay at least 🤜💥🤛 1. I have not experienced any high estradiol symptoms that I have found yet. I don't have any plans to change my current action plan to lower the estradiol. AI's are not on my list. I will re-evaluate post next test. Thank you for taking the time to evaluate my plan. Having folks with experience confirm the proper steps is re-assuring I have a little explaining to do for the rest of the reply. I didn't add every bit of information in my first post. I didn't expect the highly professional responses I have received 2. Enclo was explained - Increasing Test Anavar is for exactly what folks use it for - I am working on re-comp and cut. I was the poster child for winey shoulder issues for too long. I have spent the last few years rebuilding my shoulders and their range of motion. I am starting my 2nd (6 week) cycle and I am not ruling out a placebo effect, the 1st cycle I added 25%-30% weight to each workout Retatrutide was thrown in there for a couple of reasons - I have historically had "high normal" HDL and "high normal" LDL, but within range. My father is the same. This is the 1st time I have had HDL subfraction measured, so I unfortunately don't have a trend. With all of the Reta hype, I wanted to see if I could improve my HDL and LDL with the Reta. If I get some help burning visceral fat it would be a bonus. I have been using a very low dose - 1gm a week. I have not been using it solely for burning fat. When I decided to quit whining and fix my issues I weighed 178lbs. I am 5'9" and currently 170. The big difference is my strength and definition now vs then MK-677 I didn't mention this before, I apologize. I feel this one is almost in the same category as creatine for most. I take it 5 on 2 off. I take this as a staple for its effects, costs, reputation, and how easy it is to get a hold of Sermorelin I didn't mention before. I take a compounded troche 5 on 2 off. This was the easiest legal form of GHRH I could get. I have had a lot of thought about switching to Tesamorelin when I run out of the Sermorelin.

@Tom Hartnett Great information thank you. I didn't want to steer the conversation with any of my bias, so I didn't mention anything I was looking into. I have an appointment with a doctor tomorrow to talk about getting a prescription for Enclomiphine. AC-262 is #1 on my SARM list. Anavar is #1 on my steroid list. Do you have any advice/dosage/cycle time recommendations for either AC-262 or Avavar with the goal of discontinuing use of them in the future and regaining natural chemistry?

Ideally on the safer side of proven estimates. If experts say 6-8 weeks (chem X), my plan would be to get blood work on week 6 and decide from there with hard stop at 8 weeks. As far as doses, I would rely on the folks who have experience. I have heard a lot about the sweat spot, and that it is different for everyone. Please elaborate on the "nice test base water that's natural levels or TRT or blasting more than normal". I'm not sure what that means. For reference, I don't know what my free test is, but I will before starting a cycle. My total has averaged 450-460 the last 5 years. Recently after taking supplements my testosterone level was just over 500. Note: I have low testosterone symptoms off and on. I am expecting Enclomiphine to get me near the 800 range (?) Since my total testosterone hasn't changed much, I am assuming my free test has.