Suggested Beginner Approach Skin-focused starter: GHK-Cu (topical or low-dose injectable) + oral collagen peptides. Dual skin + fatigue: Add MOTS-c or CJC-1295/Ipamorelin (or your NAD+). A common stack in peptide clinics is GHK-Cu + MOTS-c or GHK-Cu + CJC/Ipa for synergistic collagen/energy effects. Timeline: Skin changes often noticeable in 4–12 weeks; energy can improve faster (1–4 weeks). Cycle protocols (e.g., 8–12 weeks on, 4 weeks off) prevent tolerance. 1. Top Peptide for Skin Tightening & Collagen (Neck, Face, Saggy Skin): GHK-Cu (Copper Peptide) This is the standout choice for directly supporting collagen/elastin production, improving skin firmness, elasticity, density, and reducing laxity. Studies show it tightens loose skin, repairs barrier function, and boosts fibroblast activity—exactly what you need after significant weight loss. • Why it fits: Systemic effects from injection or strong topical benefits. Many users report visible improvements in facial/neck tightness over 4–12 weeks. • Forms & beginner-friendly start: • Injectable (SubQ, most common for noticeable results): Vials often 50 mg. Reconstitute with 3 mL bac water→ ≈16.67 mg/mL concentration. Typical starting dose: 1 mg/day (≈ 0.06 mL or 6 units on a U-100 insulin syringe), possibly titrating up to 2 mg (≈ 0.12 mL or 12 units). Cycle example: 30 days on (e.g., 15 days at 1 mg, then 15 days at 2 mg), then rest. Administer before bed • Topical serum/cream (easier entry point, less invasive): 1–5% GHK-Cu applied daily to face/neck. Great starter if you want to avoid more injections initially. • • Side notes: May cause mild site irritation (rare). Pairs well with your NAD+ for overall repair. 2. For Fatigue + Bonus Skin/Muscle Benefits: Consider These Options MOTS-c (mitochondrial peptide): Excellent for cellular energy production, reducing fatigue, improving metabolism, and endurance—especially helpful post-GLP-1 when mitochondria can feel "worn out." It supports fat metabolism without suppressing appetite further.