@David Furka I'm so glad you shared that because macular degen runs in my family too. I also had not heard about that rat study. Sounds like those were injections sub Q. I've heard dripping it onto the eye or along in the tear ducts. Based on what it seems you did, that was pretty expensive, but worth it.

@David Furka When you say reaction and its not worth it, I actually do not know what side effects may come along. I can handle cold hands, but what am I missing?

@David Furka I very much appreciate the concern. Here is what I found. If you see anything that stands out as inaccurate, let me know. 🧬 What MOTS-c Does in the Body MOTS-c is a mitochondrial-derived peptide that improves metabolic efficiency, glucose utilization, and fatty acid oxidation. In simple terms, it: Encourages the body to use stored energy more effectively Enhances insulin sensitivity Can shift cellular energy production toward more efficient pathways (like oxidative phosphorylation) These are all beneficial effects — but they can also alter how heat is generated and distributed. 🥶 Why Cold Hands Might Happen Here are the likely physiological explanations: 1. Reduced Peripheral Blood Flow (Vasoconstriction) MOTS-c improves metabolic efficiency and can reduce sympathetic tone variability (your “fight or flight” balance). Some people experience a slight reduction in peripheral blood flow as the body directs more blood toward muscles or vital organs — especially at rest. This makes hands and feet feel colder, even though core body temperature remains normal. 2. Decreased Thermogenic Waste Because MOTS-c improves mitochondrial function, your cells waste less energy as heat. So you may actually be producing less “extra” heat, especially at rest — a sign of metabolic efficiency, but it can feel like being cold. 3. Lower Blood Sugar or Caloric Intake If you’ve been eating less or burning glucose more efficiently since starting MOTS-c, your body could temporarily sense a mild “energy conservation mode.” The body responds by shunting blood away from the skin and extremities to maintain core temperature. 4. Circulatory Adaptation Early phases of MOTS-c use (especially the first 1–2 weeks) can involve vascular tone adjustments — your body is recalibrating nitric oxide signaling and vascular responsiveness. ⚖️ How to Tell If It’s Benign or Not Cold hands are usually benign and temporary with MOTS-c, but here’s when to keep an eye on it: