Angela, this is true for "SOME" individuals transitioning from Tirz to Reta. So usually what they do, is add Cagrilintide to help suppress appetite. 250-500mcg twice a week, does the trick. Reta is king when it comes to weight loss. You will defintley lose more with Reta. Let me know if you need anything else :) PS-I just sold out of Cagrilintide. I should have so more in about 10 days, if you are interested.

Sure thing Jami! https://peptideheaven.com/product/cagrilintide/ Start slow. This stuff works! I have known individuals who took too much and didn't want to eat for a couple days.

Jami, all scales are gonna have a 1-3lb variance from scale to scale. Thats why I always tell people to stick to one scale. The one you have is fine. Just base your weight tracking off that one. Hope this helps :)

This is per ChatGPT.......Short answer: yes—for many people, metformin and retatrutide (“Reta”) can be used together, and the combo is fairly common in metabolic care. But there are a few important caveats to keep it safe. Here’s the clean breakdown. Why they’re often paired Metformin and retatrutide work through different but complementary pathways: - Metformin - Retatrutide (GLP-1/GIP/Glucagon agonist) Together, they can: - Improve blood sugar control - Enhance fat loss - Reduce insulin resistance more effectively than either alone Safety considerations (important) While the combo is generally safe, watch for these: 1. Low blood sugar (hypoglycemia) - Risk is low if metformin is the only diabetes med - Risk increases if you’re also using: Tip: Monitor fasting glucose when starting or titrating Reta. 2. GI side effects Both can cause: - Nausea - Diarrhea - Bloating Stacked together, this is the most common issue. How to reduce this: - Start Reta low and titrate slowly - Take metformin with food - Extended-release metformin is often better tolerated 3. Excessive appetite suppression In some people: - Calories drop too low - Protein intake suffers - Fatigue or muscle loss can occur This matters especially if your goal is fat loss + lean mass retention (which you’ve mentioned in past convos). 4. Kidney & dehydration considerations - Metformin is contraindicated in significant kidney impairment - GLP-1–type drugs can increase dehydration risk due to nausea Hydration + labs matter: - eGFR - Creatinine - B12 (long-term metformin use) Who this combo makes the most sense for ✔ Insulin resistance✔ Prediabetes or type 2 diabetes✔ Obesity/metabolic syndrome✔ Weight-loss plateaus on one agent alone Less ideal if: - You’re already very lean - You struggle to eat enough protein - You have frequent GI sensitivity Bottom line Metformin + retatrutide is generally safe and often synergistic, when dosed properly and monitored. Most issues come from going too hard, too fast, not from the combo itself.

@Diane Stevens Remember you can always get it from me Diane:) PeptideHeaven.com