I tried microdosing before and then during HRT. I had menopausal brain fog, achy joints, some hot flashes, trouble sleeping, irritability. I had trouble consistently microdosing, I think in part because things were all over and I couldn't notice improvement. But honestly, that could be because I was less in tune with my body those years. I've been on HRT for about 3 years now, symptoms have leveled out considerably. I'm recently post-menopausal and the microdosing I've done this year has been much better. Obviously, not a medical opinion, although I was honest with my menopause specialist and she didn't have concerns.