https://www.facebook.com/share/p/1CU1QfHe5u/ Johns Hopkins’ New Mebendazole Patent and Its Significance for Cancer Therapeutics A recent public news article has highlighted a development that deserves serious attention within oncology and drug-repurposing research: Johns Hopkins scientists have patented a new crystalline form of mebendazole—referred to as polymorph C—designed to enhance its anti-cancer properties. Background: Why Mebendazole Matters Mebendazole is a benzimidazole-class anthelmintic with a well-characterised safety profile accumulated over ~40 years of clinical use. Beyond its antiparasitic activity, numerous preclinical studies have demonstrated: Microtubule inhibition in cancer cells Disruption of glucose metabolism in malignant tissues Interference with multiple signalling pathways (Hh, Wnt/β-catenin, Bcl-2) Selective cytotoxicity to tumour cells at concentrations tolerated by normal cells Despite these properties, clinical adoption has been limited largely because the original molecule is off-patent, making large-scale commercial trials financially unviable. What Johns Hopkins Has Patented The new patent centers on: Polymorph C — a redesigned crystalline form This form appears to demonstrate: Improved oral absorption Higher plasma concentrations Prolonged systemic exposure Greater potency in killing cancer cells in vitro compared with existing polymorphs This is scientifically notable, because mebendazole traditionally suffers from: Poor gastrointestinal absorption High inter-individual variability Low bioavailability unless taken with high-fat meals A more bioavailable crystalline form directly addresses these limitations. Synergy Through Transporter Inhibition The Johns Hopkins team also referenced co-administration with elacridar, a potent inhibitor of: P-glycoprotein (P-gp) Breast Cancer Resistance Protein (BCRP) These efflux pumps are responsible for removing chemotherapeutic agents from cancer cells.

My wife passed on August 2 after a whole month in Hospice, she fought cancer for only 6 months,, her diagnose late January and her death in august,,,,,,,her cancer went to her brain and in a matter of two weeks she was in hospice,,,,, those who need radiation for the brain please please, think about it twice,,,, after 4 radiation treatments she went down from there,,,,,,,, just wanted to thank everyone here and to wish you strength, cure and health, I pray Gof will lead you and give you mercy, I hope we can find or establish a cure to this horrible disease one day,, With Love Jose

My Father after fighting for more than three years with immense energy and will to live passed away two weeks back. I won’t be able to say much but thank you everyone & lot of positive energy to everyone who is in this journey to defeat this disease. 🙏🏻

https://youtu.be/sgbvr1R23rw?si=04aMnRi0KOJCNJ3q

It's official. I made it 22 months progression free with several of those being NED. I have lived past my prognosis. Our son returned safely from Iraq. Each month brings more tasks completed at the farm. My tumor markers are going up. I do have progression in L5, T3 and T4 and now in my left hip. My hemoglobin dropped to levels requiring transfusion. 2 very serious hypoglycemia events. Looks like an upper GI and colonoscopy are in my future as the debilitating fatigue continues. I have seen the heart doctor. He seems most of my symptoms are related to anemia and possible blood loss. He cleared me for anesthesia and will do a heart ultrasound next week. I also see the GI doctor next week. I did have 1 dose of Zoledronic Acid. I suspect will do at least 2 maybe 3 more rounds. I have had a bone scan. No results but based on how I feel, I would not be surprised to learn there is more cancer activity. I was almost convinced to start Keytruda but it doesn't make sense for me. I do not have PDL-1 markers for efficacy and it's only 20% effective. Troldevy may be a possibility and radiation is still on the table as a palliative care and pain management option. It's fall break here in Texas so we are heading to the farm tomorrow. It's always good to get out of the city. Love and healing to you all.