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1 contribution to Castore: Built to Adapt
Sleep Issues/Feeling Wired: Looking for some feedback
I’m 38 and have always been active. I originally got into peptides using the Wolverine stack for a running-related knee injury. About 10 weeks ago I started a pretty aggressive cut while trying to maintain/build muscle. I started at 215 lbs / 24% BF by DEXA and am currently 190 lbs, estimating around 15% BF. I lift 5x/week for about an hour and run 3x/week. For most of the cut I was eating very clean, in a deficit, and very low carb. This week I increased carbs significantly and started carb cycling. Main issue: My sleep fell apart about 3 weeks ago. I used to get 6–7 hours. Now I have trouble falling asleep and/or wake up completely awake between 2–3 a.m. and struggle to get much more than 5 hours. What’s strange is I don’t feel tired at all—I feel wired and have tons of energy. Mentally and physically I actually feel great, and brain fog I used to have is gone. But obviously 5 hours of sleep isn't sustainable. I go to bed around 9 and wake at 4:15 to train. I also use blue-light glasses at night. Current stack: - CJC/Ipa – 400 mcg AM + PM (tried AM only, no improvement in sleep) - KLOW - Tirzepatide – 750 mcg 2x/week - SLU-PP-332 – 500 mcg 2x/day - 5-Amino-1MQ – 2 mg AM - Glutathione – 120 mg 3x/week - Urolithin A – daily - SS-31 – 5 mg/day (started today) - VIP – 200 mcg/day (started today) - IGF-1 LR3 – 100 mcg/day (started today) - Enclomiphene – 12.5 mg, 5x/week (started today) I was previously on retatrutide but switched to tirzepatide after my resting HR increased about 9 bpm. Since switching, HR is back to baseline. I’ve tried DSIP for the sleep issue without much success. Two of my worst nights were actually on it. I also have Epitalon and Pinealon that I purchased based on their potential effects on circadian rhythm/sleep, but haven't started them. I was planning to wait until after the SS-31 and IGF-1 LR3 cycles. One other piece that may be relevant is testosterone. About 4 years ago I was in the 200s. Two months ago I tested at 640 total / 15.2 free, which surprised me. Yesterday I tested again at 384 total, SHBG 24, LH 6.4 (free wasn't tested). Previous LH was 4.7. I've also been using ashwagandha, zinc, boron and tongkat ali for the last couple months.
1 like • 9d
@Nathan Eckstein Thank you for the feedback. I currently am taking glutathione in the morning most days but did take it later in the day a few times. I did not realize it could potentially affect sleep. I will have to look into this a little more, thanks.
0 likes • 7d
@Anthony Castore Really appreciate the detailed response. A lot of what you said makes sense, especially the aggressive cut, low carbs and training volume all potentially adding up and keeping my system in that wired state. I wasn’t tracking calories closely, but I know I was substantially under maintenance most days and was eating less than 50g of carbs a day. This week I made a pretty big change and am now around 300g of carbs a day with carb cycling. My shorter weekday runs are in the afternoon and aren’t fasted. My longer Saturday morning run is fasted. Caffeine probably isn’t much of a factor either. I used to drink multiple cups of coffee a day, but now I might have a couple cups total in a week. I think I’m going to start with the food/recovery side like you suggested. Bring calories back closer to maintenance for 7–10 days, keep the carbs higher and put a good amount at dinner, stay on top of hydration/electrolytes and back the running down some while I see what happens with the sleep. I’ll also work on the light timing you mentioned. I actually started using a CGM earlier this week. So far I haven’t seen any substantial drop in glucose that lines up with me waking up between 2–3 a.m. I’m going to keep watching it and see if anything shows up over the next couple weeks, but so far it doesn’t look like there is an obvious glucose crash happening when I wake up. The SS-31, VIP, IGF-1 LR3 and enclomiphene were all started after the sleep issue had already been going on for about 3 weeks. I do agree though that adding several things at the same time makes it harder to figure out what is doing what from here. Moving forward I going to decrease the variable and not run so many peptides at the same time. On the testosterone, both the 640 and 384 tests were done fasted around 9 a.m., so the testing conditions were actually pretty similar. I agree it probably makes sense to get calories and sleep stabilized and then run a more complete panel again.
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Kevin Andersen
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@kevin-andersen-5992
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Joined Sep 3, 2026
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