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3 contributions to The Methylation Hub
"Connecting the dots: Migraines, cognitive decline, and MTHFR"
Hello, thank you for sharing information about this topic. In Spain, people have no idea that this genetic mutation exists and that it can affect you so much in the long run. Doctors never test your homocysteine levels, and if you finally manage to convince one to order it in your bloodwork, they don't know what to do with the results afterwards. It’s unbelievable!! I believe in preventive medicine... I've suffered from migraines since I was 20, and my mother was diagnosed with cognitive decline 10 years ago. Ever since then, my search for answers began... and in the end, I had to diagnose the genetic mutation myself, researching and studying on my own. That's how I found you on Instagram and later on Skool. I have finally managed to get a hematologist to order the genetic test; I had it done yesterday, Tuesday, and I will have the results soon. I am already supplementing and managed to bring my homocysteine down from 53 to 30... but I still have a way to go. Thank you for all the valuable content you provide on this blog. Best regards.
0 likes • 11d
Hi there! I am 52, have homozygous C677T, my mom was diagnosed with Early Onset Alzheimer's/cognitive decline 2 years ago @ 72, and I am on a mission to positively align my destiny!! My homocysteine has increased from 12.7 (June 2024) to 20.5 (February 2026). I have taken to ordering (and paying out of pocket) to have it monitored. Curious to hear how you have decreased your level so much (good for you!!!!)....
Introduction
I am homozygot C677T together with a Protein z deficiency. This was discovered after 3 miscarriages in my midthirties, now I am 54. Via Instagram I found this information for the right form of supplements but still suffer from instable periods and migraine. I am coming from Germany.
0 likes • May 12
Have you considered HRT?
Introduction
Hello! I am Kerri from Philadelphia, PA and am Homogenous C677T (w/Slow COMT). I have been diagnosed with chronic Epstein Barr, Long Term Lyme, Osteoarthritis (have had both my hips replaced and need my knees done), and anxiety. Thankful to have found this community!! I am a High School Psychologist, wife to an amazing brewer, mom to two sons (17 & 21), and daughter to a mother recently diagnosed with Early Onset Alzheimer's. My health journey has lead me to the power of knowledge and how much the US allows in our foods and products. My biggest concern right now is my elevated homocysteine (20.5) levels and the lack of understanding by the primary, gyn, and cardiologist. I am so excited to have a place to come for research-based information!!!
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Kerri Barrar
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@kerri-barrar-1368
I’m Kerri. 52 year old with Chronic Epstein Barr and long term Lyme. I have Homogeneous C677T MTHFR variant and slow COMT with high homocysteine.

Active 23h ago
Joined May 12, 2026