I do mine on my day off, anywhere between 10-12 in the morning. I have coffee, some high protein foods, and a whole tumbler of water. I don't feel any effects that day, if I feel like food not digesting, it's the second day. I eat clean protiens that day and very low carbs, they seem to feel like they sit in my gut and don't move. To be clear, I'm not sick, just a little ish - but nothing that affects my day or doing anything I want. It's just a very full, food not digesting feeling. Then I'm usually fine day three thru next jab. Everyone is different, but first shot felt nothing til I woke the next day... Almost 24 hours. It was a 1.5 dose... But it worked immediately first week for me. I think whatever works into your schedule is up to you. I only say, the first shot, do it first thing in the morning, to see how you feel through out the day. To Jab and sleep, only to wake up feeling like shit would have freaked me out. Unless you're hyper responsive... You shouldn't notice anything for most of the day, at best maybe some suppression at supper. But honestly I don't have jack for side effects besides what I said above. I'd rather know side effects by evening, before I woke up the next day feeling like a$$😂- but that's me. Next shot, do what you feel is best, as long as you take shot that day (day seven). It don't really matter when, AM or PM.