Glutathione is generally not considered a substance that requires “cycling” in the way some hormones, stimulants, or performance-enhancing compounds do. People often use it: - daily, - several times weekly, - or in periodic courses, depending on the reason (general wellness, antioxidant support, liver support, skin concerns, recovery, etc.). That said: - Long-term high-dose use hasn’t been studied as extensively as short-term use. Potential side effects can include: - GI upset, - bloating, - cramps