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Owned by Jean-marc

If your genetics have left you confused, you're in the right place. Integrative Medicine Doctor, MD & MTHFR specialist.

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40 contributions to The Methylation Hub
Case Study : Methyl Trapping and comes what comes next Inside the Hub
Saturday recording is here. Today I discussed a case in the order of the Archive, going through the different modules. Case study: 38-year-old woman, wired, anxious, disrupted sleep after starting methylfolate She is Compound Heterozygous: one copy of C677T and one copy of A1298C Your questions are welcome!
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Case Study : Methyl Trapping and comes what comes next Inside the Hub
Live this week is 📅 Saturday 26 September, 8 PM UK / 3 PM ET / 12 PM PT
Did a supplement ever make you feel worse? Methylfolate that left you wired at 3am. B12 that did nothing. A protocol that worked for your friend and flattened you. Next live, I'm walking one patient through all seven Archive modules to show why that happens. It is rarely the wrong supplement. Usually it is the right one, taken in the wrong order. We'll cover: - Why a "normal" homocysteine of 13 can still mean the cycle is struggling - The folate trap: plenty of folate on paper, cells short of it - How four years on an acid blocker can undo a perfect protocol - The case that plateaued, and where the answer lives in the next release I'll also explain what changes on 1 October. Modules 1–7 stay free, permanently, and the second half of the Archive opens for members. Tell me below: what did you take, and how did you feel? I'll use your stories on the live (anonymously) and answer as many as I can. 📅 Saturday 26 September, 8 PM UK / 3 PM ET / 12 PM PT 🎥 The recording goes into the Archive. Education, not personal medical advice. Dr Jean-Marc
1 like • 6d
@Gemma Cowling it can happen you can reduce the dose or spread the dose 1/2 the dose twice a day or even try a different brand
0 likes • 6d
@Gemma Cowling maybe a different brand then of look at your gut health ?
New Modules in the Archive just released
Great news, I just released 4 new modules from the Archive in the Classroom COMT and neurotransmitters Homocysteine Gut Health Why Supplements Can Backfire Let me know what you think; looking forward to hearing from you.😀
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MTHFR
Hi, I am compound heterozygous, one of each variant. I also have APOe4, slow DAO, fast MAOA, intermediate COMT. I have all the symptoms! To many to name but all the normal ones, I manage. I want to feel better overall and lose weight. No doctor western or functional has connected the dots for me. Can you help, do you have any recommendations? My exercise, sleep, diet and supplements are all on par with MTHFR protocol. But something is missing, can you help.
0 likes • 16d
In many cases the issue starts in the gut, your genetic picture is complex , labs will help as well
WHAT IS HAPPENING NEXT
will be posted soon , Grand rounf presentation at Fountain life ( Longevity Clinic in the US) , topic is ablut methylation MTHFR Genes and BH$ and how the 2 are connected
WHAT IS HAPPENING NEXT
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Jean-marc Sobczyk
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@jean-marc-sobczyk-8042
Integrative physician & MTHFR specialist. If your genetics have left you confused, you're in the right place. MD · ND · 25 yrs experience.

Active 5h ago
Joined Aug 22, 2025
London UK