Thanks @Tony Huge, I’m curious what dose pregnenolone do you take and time of day? I’m guessing, from your video, one of the reasons you take it is due to the cascade effect to progesterone and then towards allopregnanolone, a neurosteroid that directly and powerfully activates GABA-A receptors in the brain producing a calming and anti-anxiety effect? What’s your thoughts / experiences on taking progesterone directly for a more targeted direct root of this mechanism? If so, what would be a typical dose for this? Thank you!

Thyroid hormone?

@Drew Griffin I personally wouldn't know, I've just started learning more about thyroid hormones. But it's a good question! Let's hope someone else can comment.

@Bryan J the exact same thing happened with me on the same dose. I dropped to 6.25mg daily, it improved a bit, but reversed once I stopped altogether. Others have suggested it could have worked better with an even lower dose, and taking it less frequently 2 x week. For me sleep is critical, otherwise it negatively impacts everything else. People seem to either love it or hate it. I believe the reason for this is due to genetics. If someone is a carrier of the CYP2D6 +/+ homozygous variant (poor/intermediate metabolizer), enclomiphene clears much more slowly than standard dosing assumes. A standard starting dose of 12.5mg likely produces an effective exposure closer to what 25-40mg would produce in a normal metabolizer, and the elimination half-life, already around 10 days in normal metabolizers, may extend to 15-20+ days. This means each daily dose stacks on top of a much larger remaining amount than intended, compounding toward a substantially higher steady-state level, directly explaining the overstimulation and nervous system disruption some people experience. @Tony Huge would be keen to hear your thoughts on the genetics part.

@Kevin Beaufrand thanks for sharing. Great that you get no sides for this protocol! May I ask, what benefits do you feel?

@Lakis Halkias thanks for sharing, so to summarize my understanding, you are gaining a measurable boost in recovery markers when combining RAD 140 with Testosterone, and you would like to understand what is the mechanism? I personally, can't tell you, but it's a very interesting observation. May I ask what was your average HRV and lowest HR at night? And what is it when you take RAD 140? I am curious how much the difference is? Thanks!

@Alan Farina thanks for sharing your experience. How was your journey stopping TRT? May I ask when did you get blood work, meaning did you let enclomiphene and/or RAD washout first?

@Alan Farina thanks for sharing. A lot of moving variables at play there, which can make decision making quite complicated. However, at least you know you felt better on TRT, and you haven't so far been able to replicate that with enclo. It can be a very delicate process, especially when trying different things can lead to feel like trash in the process.