Live cultures die over shelf life. A product declaring 50 billion CFU at time of manufacture is telling you what was in there when it left the factory, not what is in there now. A product declaring 10 billion guaranteed through the expiration date is making the harder promise, and the harder promise is worth more. ISAPP, the scientific association for probiotics, says potency should be listed through the expiration date for exactly this reason. Second thing while you have it in your hand. A strain needs three parts: genus, species, and the strain code — the letters and numbers on the end. Without the code you cannot tie what you bought to any trial, because two strains with the same species name can behave completely differently. Go and look at yours. Does it say at manufacture or through expiry, and does it give you the strain codes?