Just order Kisspeptin! Excited to try this one! 🩷🩷🩷

When is the best time to pin KLOW? Morning or night? Does it cause headaches?

Kisspeptin (also known as metastin) is a naturally occurring neuropeptide hormone encoded by the KISS1 gene. It serves as the primary upstream regulator of the hypothalamic-pituitary-gonadal (HPG) axis, stimulating the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus. This, in turn, triggers the pituitary gland to secrete luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which drive reproductive functions like puberty onset, gametogenesis, and sex steroid production. Discovery and Structure Researchers first identified the KISS1 gene in 1996 in Hershey, Pennsylvania (hence the name, inspired by Hershey's Kisses), as a suppressor of metastasis in melanoma cells. Later studies revealed its critical role in reproduction. Mutations in KISS1 or its receptor (KISS1R, formerly GPR54) cause hypogonadotropic hypogonadism and failure to enter puberty in both humans and animals. Kisspeptin exists as several isoforms derived from a 145-amino-acid precursor: - Kisspeptin-54 (KP-54, the longest and most abundant in circulation). - Shorter active fragments: Kisspeptin-14, -13, and -10 (KP-10, the minimal sequence retaining full bioactivity, often used in research). All isoforms share a conserved C-terminal RF-amide sequence essential for receptor binding. In research settings, Kisspeptin-10 is the most commonly studied synthetic version due to its potency and simplicity. Mechanism of Action Kisspeptin binds to the G-protein-coupled receptor KISS1R (GPR54) on GnRH neurons. This activates the Gq/11 pathway, leading to: - Phospholipase C activation. - Increased intracellular calcium. - Depolarization of GnRH neurons. It can also engage MAPK/ERK and other pathways. Kisspeptin acts upstream of GnRH, making it a "master regulator" of the reproductive axis. It responds to sex steroid feedback (positive and negative) and integrates signals related to energy balance, metabolism, and stress. Emerging research also links it to insulin secretion, metabolism regulation, and brain regions involved in emotion, mood, and sexual behavior.

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Happy to say that I am under the 200 mark. 192 lbs. not my target weight yet but stoked to break under that mark. Haven’t been below 200 in years now.