@Christy White that is so interesting! I have never heard that! I wonder if @Tara West could weigh in on that? Have you ever tried KPV? That one has been so helpful for me across the board and hear others say the same!

@Arlene Wells I’m doing 50mg 5 days on 2 off per Tara’s NAD+ podcast. I worked up to 50 slowly from 25 mg but the regularity of the 5 days has been great for me. I have read in other places that it is good to do 4-6 weeks of a loading phase which is 30-50mg daily or 5 days for 4-6 weeks and then can move towards an e/o day or 3 days a week schedule. I’m loving the 50 mg right now though. Lots of great not stimulating energy and lots of mental clarity. Mood has been great as well.

I’ve never tried it but was thinking about doing it this summer. I’ve heard good things but I’ve never heard it’s painful! Painful how? GHK-cu burn? Most painful injections I have done glute IM and never have an issue at all!!

Just my opinion based on my own experience but it’s sounds like given your nutrition and exercise habits you are someone that would have success given that you have the important components in place. I do hear lots of people say that GLP-1s cause constipation for them and even gastroparesis in extreme cases, but for me it has done the opposite. I have struggled for years with constipation but starting Tirz originally and then switching at Reta has fixed that for me completely. I am now completely regular. It has been wonderful and constipation is never an issue! Definitely one of many benefits I wasn’t expecting! I would say just start a super low dose and pay very close attention to your regularity. Also, make sure you are drinking tons of water and using electrolytes. Reta has made me less thirsty so I have to be more intentional about meeting my daily water goal than I have ever been. Good luck!!

@Shawna Fenwick I have definitely noticed growth in terms of length. People are actually commenting on how long it’s getting so I think it’s growing more quickly. I haven’t noticed change in thickness or new hair growth yet. My nail person has also been commenting on how strong my nails are and how quickly they are growing. I always have them done so she checks to see if they are getting weaker and tells me when to take a break and she just said the other day that she couldn’t believe that they were just not getting weaker at all! My skin is also feeling really soft and I’m not currently on a cycle of GHK-cu so I definitely think it is related to this blend.

Sorry to hear about your hair incident. That sounds so painful!!!!

So, @Giddyup H, my understanding on both of those is that Tesofensine impacts your neurotransmitters so for some people with certain brain chemistry and can be amazing and they love it, for others, with different levels of brain chemistry it isn’t great. I think you would just need to start at a really low dose and see how you feel. I do know that Orforglipron works on entirely different receptors than Tirz or Reta. I could be wrong about this but I want to say it’s not actually a peptide so it doesn’t operate the same way at all. For that reason lots of people use it when they want to give their receptors a break but continue with their progress or maintain the additional health benefits they are receiving from a GLP-1.

@Giddyup H I think it is a GLP but it’s a small molecule and not a peptide which is why it holds up in the pill form but works on different pathways in the body to create the same effects as the GLP peptides.