Some benefits of Niacin: - Activates about 400 known detoxification enzymes including our favorite families of enzymes like ADH and ALDH - Provides the building block for more NAD and ATP synthesis. - Building block for more DNA synthesis, protection and repair. - Increases bile production and excretion for more rapid detoxification via the poop. - Stimulates tight junctions in the intestine, liver, brain etc. that literally “knit” cells together in an orderly sheet. - Important nutrient for the immune system - Stimulates the expression and function of toxin transport channels on the cell membranes, one of those being the p-glycoprotein family, and other organic acid transporters/bilirubin transporters, bile acid transporters, etc. - At higher doses such as 500mg to 1000mg it will lower LDL cholesterol and increase HDL