Your Progesterone Problem, is not a Progesterone Problem.
Here is the reason your progesterone is low and it has absolutely nothing to do with progesterone.
It starts with leptin. And most practitioners aren't talking about this.
When you never see the morning sun, or you're eating late at night, get too much blue light, workout too late, your brain stops receiving leptin's signal. And when leptin goes quiet, your hypothalamus interprets that as famine.
But before it even gets to your sex hormones your mitochondria shift. They exit hormone production mode and activate what's called the Cell Danger Response. Steroid hormone synthesis — cortisol, progesterone, estrogen gets quietly deprioritized.
Then your adrenals compensate.
Cortisol spikes to stabilize blood sugar.
And cortisol doesn't just compete with progesterone, it actively blocks progesterone receptors.
Here's where it gets interesting.
Leptin is what drives TRH, which drives TSH, which drives your thyroid output. It's what maintains the pulsatility of GnRH = the signal that tells your brain to produce LH and FSH.
Without adequate leptin signaling, that entire axis starts to flatten.
So by the time we're talking about low progesterone, we are already eight steps downstream of the actual problem.
Every system is responding accurately to one broken upstream signal.
Any questions, share below.
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Josh Rubin
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Your Progesterone Problem, is not a Progesterone Problem.
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