Leptin: The Circadian Signing Hormone

Josh Rubin

May 20 • 🏠 Homebase

High vs. Low Leptin — same thing or different?

The short answer: Both.

🔹 The Similarities

Whether leptin is high or low, the outcome is often the same:

➡️ Leptin resistance

➡️ Sugar-burning 24/7 (not fat)

➡️ Chronic stress in the system

➡️ Disrupted glucose + insulin balance

In both cases, the body isn’t “hearing” leptin’s signals.

🔹 The Differences

⚠️ High leptin = plenty of fuel, but the brain can’t read it. Think “too much noise.” The message gets lost, and the body behaves as if it’s starving—so appetite increases, fat burning shuts down, stress stays high.

⚠️ Low leptin = true scarcity/famine.

There’s not enough leptin to signal safety, so the body knows it’s starving. Thyroid slows, adrenals bottom out, hormones drop, metabolism grinds to a halt.

So while both states create resistance and stress, one is like having the radio too loud (high leptin) and the other is like the radio being unplugged (low leptin).

Either way—the message isn’t getting through.

🔹 The Real Fix

It’s not about more dieting, restriction, adrenal or thyroid supplements, GLP1 💉 or “just add calories.

It’s about restoring leptin sensitivity so your metabolism can self-correct and your nervous system can finally feel safe. 🌱

If you tried everything and still feel stuck, START HERE.

9:06

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Leptin: The Circadian Signing Hormone