KPV is a naturally occurring tripeptide fragment of alpha-MSH (melanocyte-stimulating hormone). Unlike its parent compound, KPV doesn’t affect pigmentation. Instead, it’s being looked at for its anti-inflammatory, gut-protective, and skin-healing properties. 🔬 Mechanisms of Action KPV’s main effects come from its ability to calm down overactive inflammation: - NF-κB inhibition → This transcription factor drives many inflammatory pathways. Blocking it reduces pro-inflammatory cytokines (like TNF-α, IL-6). - Mast cell stabilization → Helps reduce histamine release, which plays a role in allergies and gut inflammation. - Gut barrier support → Appears to strengthen tight junctions in the intestinal lining, reducing “leaky gut.” - Antimicrobial effects → Shown in research to reduce bacterial overgrowth and infections in the gut and skin. 💉 Injectable Benefits (SubQ or IM) When injected, KPV goes systemic, offering broader effects: - Systemic inflammation control – Potential for autoimmune-related inflammation, joint pain, and skin flare-ups. - Skin health – May help reduce redness, eczema, psoriasis, and acne inflammation. - Recovery & repair – By calming immune overactivation, it may support faster recovery from stress, training, or tissue irritation. Typical research ranges: - 200–500 mcg once or twice daily (subcutaneous) - Some studies explore up to 1 mg/day - Timing: Often morning and/or evening, depending on systemic inflammation goals. - Duration: Cycles of 4–8 weeks, then reassess. 💊 Oral Benefits KPV is also uniquely stable when taken orally, making it especially interesting for gut health: - Gut inflammation – Helps with colitis-like symptoms, IBD, and general gut irritation. - Strengthens gut barrier – Supports tight junction integrity to reduce permeability (“leaky gut”). - Allergic responses – May calm food sensitivities by reducing histamine and mast cell activation. - Microbiome balance – Shown to decrease harmful bacterial activity in the gut lining.

Got my first order from Peptira. First, let me tell you, these folks at Peptira are serious when it comes to labeling. The actual content quantity is on the label, so no more writing on the vials of how much product is in it. Much easier to store and when reconstituting with correct amount of BAC water. 10/10 for these guys!